化痰活血汤对后循环梗死性眩晕脑血流及临床症状的影响

Effects of Phlegm-resolving Blood-activating Decoction on Clinical Symptoms and Cerebral Blood Flow of Posterior Circulation Infarction Vertigo

目的:观察化痰活血汤治疗后循环梗死性眩晕的临床疗效及作用机制。方法:将后循环梗死性眩晕患者100例按随机数字表法分为观察组、对照组各50例,在对症支持治疗基础上,对照组使用氟桂利嗪治疗,观察组联合化痰活血汤治疗,比较2组患者治疗前后椎动脉内径、平均血流、阻力指数及临床疗效。结果:治疗后2组患者椎动脉内径、平均血流均高于治疗前(P<0.05),阻力指数低于治疗前(P<0.05),观察组患者椎动脉内径、平均血流均高于对照组(P<0.05),阻力指数低于对照组(P<0.05);治疗后2组患者颈项部疼痛、头晕头痛及恶心呕吐评分均低于治疗前(P<0.05),观察组低于对照组(P<0.05);观察组有效率为94.0%,高于对照组的80.0%(P<0.05)。结论:化痰活血汤能改善后循环梗死性眩晕患者椎动脉内径,提高脑血流,降低脑血管阻力,改善患者临床症状。

Objective： To observe the clinical effects and the mechanism of phlegm-resolving blood-activatingdecoction in treating posterior circulation infarction vertigo. Methods： Eighty patients with posterior circulationinfarction vertigo were divided into the observation group and the control group by random number table method, 50cases each group. On the foundation of the symptomatic supportive therapy, the control group accepted flunarizineand the observation group were given phlegm-resolving blood-activating decocton besides flunarizine. Vertebralartery diameter, mean blood flow, drag index and clinical effects were compared in two groups before and afterintervention. Results： Vertebral artery diameter and mean blood flow of the patients in both groups after theintervention were higher than these before the intervention（P〈0.05）, drag index was lower than that before theintervention （P〈0.05）, the observation group was higher than the control group in vertebral artery diameter andmean blood flow （P〈0.05）, lower than than the control group in drag index（P〈0.05）; the scales of neck pain,vertigo and headache, nausea and vomiting of the patients in both groups after the intervention were lower than thesebefore the intervention（P〈0.05）, the observation group was lower than the control group（P〈0.05）; the effectiverate of the observation group was 94.0% , higher than 80.0% of the control group（P〈0.05）. Conclusion：Phlegm-resolving blood- activating decoction could effectively improve vertebral artery diameter, raise cerebralblood flow and decrease cerebral vascular resistance, as well as improve clinical symptoms.