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顺铂子宫动脉介入栓塞联合紫杉醇静脉化疗治疗局部晚期宫颈癌的效果分析 被引量:12

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摘要 目的探讨顺铂子宫动脉介入栓塞联合紫杉醇静脉化疗治疗局部晚期宫颈癌的效果。方法按随机数表法将50例局部晚期宫颈癌患者分成对照组和观察组,各25例。对照组患者接受紫杉醇静脉化疗,紫杉醇剂量为135 mg/m2,经静脉给药。观察组接受顺铂子宫动脉介入栓塞联合紫杉醇静脉化疗,紫杉醇用药方法同对照组,顺铂按70 mg/m2经子宫动脉插管灌注后利用明胶海绵颗粒对双侧子宫动脉进行栓塞。治疗结束2周后进行根治性子宫切除术、盆腔淋巴清扫术,对比近期疗效。结果对照组完全缓解10例,部分缓解4例,稳定6例,进展5例,治疗总有效率为56.00%(14/25);观察组完全缓解19例,部分缓解5例,稳定1例,进展0例,治疗总有效率为96.00%(24/25)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论顺铂子宫动脉介入栓塞和紫杉醇静脉化疗联合应用治疗局部晚期宫颈癌效果较好,可有效控制肿瘤进展。
作者 李永正
出处 《河南医学研究》 CAS 2018年第6期1082-1083,共2页 Henan Medical Research
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