Y-box结合蛋白-1和细胞周期蛋白D1在前列腺癌中的表达及其临床意义

Expressions of Y-Box binding protein-1 and cyclin D1 in the prostate cancer

目的探讨Y-box结合蛋白-1(YB-1)和细胞周期蛋白D1(cyclin D1)在前列腺组织中的表达水平及临床意义。方法收集122例前列腺癌标本及60例良性前列腺增生标本,采用免疫组化S-P法检测YB-1和cyclin D1蛋白的表达水平;并分析两者与前列腺癌患者临床病理参数的相关性。结果前列腺癌组织中YB-1、cyclin D1表达的阳性率均高于前列腺增生组织,差异有统计学意义(P<0.05)。前列腺癌组织中YB-1、cyclin D1的表达与PSA水平、临床分期、Gleason评分有关,差异有统计学意义(P<0.05)。前列腺癌组织中YB-1与cyclin D1的表达呈正相关(r=0.459,P<0.05)。结论前列腺癌组织中YB-1、cyclin D1高表达,且与PSA水平、临床分期、Gleason评分有关。

Objective To investigate the expressions of Y-Box binding protein-1 and Cyclin D1 in the prostate cancer and clinical signficance. Methods Immunohistochemical S-P mathod was used to detect the expressions of YB-1 and cyclin D1 in the 122 cases of prostate cancer and 60 cases of benign prostate hyperplasia（ BPH）. The relationship between YB-1,cyclin D1 and clinicopathlogical parameters were analyzed. Results The positive rates of YB-1 and cyclin D1 in the prostate cancer were significantly higher than those in the BPH（ P〈0. 05）. The expressions of YB-1 and cyclin D1 in the prostate cancer were related with PSA,Gleason score and clinical tumor stage,the difference was statistically significant（ P〈0. 05）. In the prostate cancer,the expression of YB-1 was positively related with cyclin D1（ r = 0. 459,P〈0. 05）. Conclusion The expressions of YB-1 and cyclin D1 are higher in the prostate cancer than BPH,and are related with PSA,Gleason score and clinical tumor stage.