C型凝集素受体CLR对树突状细胞功能的调控效应

Effects of C-type lectin receptors on functional regulation of dendritic cells

树突状细胞(Dendritic cells,DC)是专职性抗原提呈细胞,其表面表达的C型凝集素受体(C-type lectin receptors,CLR)在DC的摄取糖蛋白和识别微生物抗原,并将抗原信息提呈给T、B淋巴细胞的过程中发挥重要作用,从而在调节抗真菌寄生虫感染、过敏反应和肿瘤免疫中扮演重要角色。故通过研究C型凝集素受体对DC功能的调控效应来深入了解疾病的发生发展并进一步调控其过程具有重要意义。本文将对近期相关研究成果作一综述。

Dendritic cells are the most potent professional antigen presenting cells. The expression of C-type lectin receptors（ CLR） contributes to the intake of glycoprotein and identification of microbial antigens,which results in antigen information presented to T and B lymphocytes and the ensuing adaptive immune response. The process plays an important role in antifungal or anti-parasitic infection immunity,allergic reactions and tumor immunity. Therefore,it is of great significance to explore the effect of C-type lectin receptors on the regulation of DC function and the development of diseases. The review focuses on the recent research findings on the effect of CLR members on the functional regualtion of DC.