抗苗勒管激素联合基础FSH及FSH/LH对生育高龄女性卵巢功能储备的评估

Assessments of Anti-Mullerian hormone combining with FSH and FSH/LH in the advanced maternal women during the reproductive year with ovarian reserve

目的研究抗苗勒管激素联合基础卵泡刺激素(FSH)及FSH/LH对生育高龄女性卵巢功能储备的评估,以此评价生育高龄女性的生育功能。方法选择2015年8月~2016年5月门诊60例生育高龄(>35岁)女性有生育要求患者为研究组,另选60例20~35岁育龄期健康者为对照组,检测两组患者的血清基础抗苗勒管激素(AMH)、卵泡刺激素(FSH)、黄体生成激素(LH)并做相关性分析。结果研究组AMH水平明显低于对照组差异有统计学意义(P<0.05);研究组FSH水平明显高于对照组,差异有统计学意义(P<0.05);LH水平则低于对照组,但无统计学意义(P>0.05);研究组组FSH/LH较对照组高,差异有统计学意义(P<0.05);AMH与年龄、FSH、FSH/LH呈负相关(P<0.001);AMH与LH无相关性(P>0.05)。结论年龄、AMH、FSH及FSH/LH与卵巢储备功能密切相关,结合女性年龄,有助于评估生育高龄女性的卵巢储备功能。

Objective To assess Anti-Mullerian hormone combining with FSH and FSH/LH in the advanced maternal women during the reproductive year with ovarian reserve and evaluate the function of the reproductive function of the advanced maternal women during the reproductive year.Methods 60 patients with the advanced maternal women during the reproductive year（35 years old）from clinic outpatient were randomly selected.60 healthy volunteers from August 2015 to May 2016 were selected as control group.Te serum Anti-Mullerian Hormone（AMH）,follicle stimulating hormone（FSH）and hormone progesterone（LH）were measured.Results AMH level of the advanced maternal age（〉35 years old）group was lower than that of control group（P〈0.05）.FSH level of the advanced maternal age（〉35 years old）was higher than that of control group（P〈0.05）.The follicle-stimulating hormone/luteinizing hormone ratio of the advanced maternal age（〉35 years old）was higher than that of control group（P〈0.05）.There was negative correlation between AMH and age,FSH and FSH/LH（P〈0.05）.There was no correlation between AMH and LH（P〈0.05）.Conclusion The age,AMH,FSH/LH and FSH were closely related to the ovarian reserve.It will be helpful to assess the ovarian reserve function in the advanced maternal women during the reproductive year combining with the age.