功能化纳米石墨烯在肿瘤诊断方面的应用研究进展

Research on Cancer Therapies of Functionalized Nano-graphene

石墨烯以其独特的二维周期平面结构和优异的电学、光学及力学性质在化学、物理和材料学界引起了广泛的研究兴趣。目前,表面修饰提高石墨烯材料在生物体内的稳定性和相容性,使得功能化纳米石墨烯应用于生物医药领域成为可能。本文简述了通过利用纳米石墨烯在近红外区的强吸收,有可能在肿瘤诊断方面的应用,对它在体内体外的行为和潜在的毒性进行了评述。

Graphene has been extensively explored for applications in a large variety of fields including chemistry,physics and material science due to its unique two-dimensional structure and outstanding electrical,optical,and mechanical properties.It is well known that the surface modification of nano-graphene is the key to improve the biocompatibility of nano-graphene and control their behaviors in biological systems.Therefore,functionalized nano-graphene attracted tremendous interest in biomedicine in recent years.According to the domestic and international literatures,functionalized nano-graphene has also been used as photothermal agents for in vivocancer treatment by utilizing their intrinsic high near-infrared absorbance.In addition,the behaviors and potential toxicity of graphene-based materials in vitro and in vivo have been studied.Finally,future prospects and challenges of using graphene-based materials for theranostic applications are reviewed.