美托洛尔联合曲美他嗪在不稳定性心绞痛患者中的临床治疗效果及对心功能的效果评估

Clinical efficacy of metoprolol combined with trimetazidine in patients with unstable angina and assessment of cardiac function

目的探讨美托洛尔联合曲美他嗪对不稳定性心绞痛患者施治后获得的临床效果,并且观察对其心功能产生的影响。方法选择108例不稳定性心绞痛患者作为实验对象;所有不稳定性心绞痛患者通过数字奇偶法展开随机分组;对照组(54例):选择常规疗法完成不稳定性心绞痛患者疾病治疗;观察组(54例):选择常规疗法+美托洛尔+曲美他嗪完成不稳定性心绞痛患者疾病治疗,最终就两组不稳定性心绞痛患者心功能表现、心绞痛疗效以及治疗不良反应表现展开对比。结果与对照组患者心功能表现对比,观察组不稳定性心绞痛患者LVEF水平以及SV水平改善程度显著(P<0.05);观察组患者治疗总有效率为98.15%,对照组为75.93%,观察组高于对照组(P<0.05);两组患者不良反应发生情况比较差异无统计学意义。结论临床合理选择美托洛尔+曲美他嗪药物对不稳定性心绞痛患者施治,于心功能改善以及心绞痛疗效提高两方面可以做出充分保证,并且未呈现出显著用药不良反应现象,从而为不稳定性心绞痛患者病情恢复加以显著促进。

Objective To investigate the clinical effect of metoprolol ＋ trimetazidine on patients with unstable angina pectoris and to observe its influence on cardiac function. Methods A total of 108 patients with unstable angina who were admitted to our hospital from June 2015 to May 2017 were selected as experimental subjects. All patients with unstable angina were randomly divided into two groups according to the number parity method. Control group（n=54） treatment of unstable angina patients to complete the treatment of disease; observation group（54 cases）： the choice of conventional therapy ＋ metoprolol ＋ trimetazidine treatment of unstable angina patients, and ultimately patients with unstable angina pectoris Performance, angina pectoris and treatment side effects contrast. Results Compared with the patients in the control group, the level of LVEF and the level of SV in the patients with unstable angina were significantly improved（P〈0.05）. The total effective rate was 98.15% in the observation group,75.93% in the control group, and the observation group was higher than the control group（P〈0.05）. There was no statistically significant difference in adverse reactions between the two groups. Conclusion The clinical choice of metoprolol ＋ trimetazidine in patients with unstable angina pectoris can be adequately guaranteed in two aspects： improvement of cardiac function and improvement of angina pectoris, and no significant side effects of medication are observed. Thus for the recovery of patients with unstable angina improved significantly.