阿达木单抗联合甲氨蝶呤治疗银屑病患者3例临床观察

Clinical study on effect of adalimumab combined with methotrexate in treating three cases of psoriasis

目的:观察阿达木单抗联合甲氨蝶呤治疗银屑病的临床疗效。方法:应用阿达木单抗联合甲氨蝶呤治疗3例中重度银屑病患者,对其皮损及关节治疗的有效程度进行临床观察。结果:3例患者的皮损及关节症状均明显改善,治疗8周后患者皮损改善可达PASI 50以上,治疗18周可达PASI 75以上。结论:阿达木单抗联合甲氨蝶呤治疗银屑病,对患者皮肤损害有明显疗效,同时可改善银屑病合并结膜炎等不适症状。

Objective： To evaluate the efficacy and safety of adalimumab combined with methotrexate treating three cases of psoriasis. Methods： Clinical observation： 3 patients were treated with adalimumab at a starting dose of 80 mg subcutaneously at admission,then 40 mg total dose subcutaneously every other week starting at week 2,combined with methotrexate 10 mg intravenous dripped for 18 weeks. The safety was checked,and the changes of modified psoriasis area severity index（ PASI）,as well as the conditions of skin lesions and symptoms improving time were compared. Results： Clinical observations show that the efficacy rates were over PASI 50 in the 8th week and PASI 75 in the 18th week respectively. Conclusion： Adalimumab combined with methotrexate is effective and safe topical agent for the treatment of psoriasis,it can also anesis the nail damage and combined conjunctivitis.