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痒疹样营养不良型大疱性表皮松解症1例 被引量：1

A case of dystrophic epidermolysis bullosa
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摘要 报告1例痒疹样营养不良型大疱性表皮松解症。患者男,35岁。双小腿丘疹、结节伴瘙痒4年余。皮肤科检查:双小腿伸侧皮肤密集米粒至黄豆大暗红色丘疹、结节,部分皮损表面有鳞屑、结痂,无明显水疱,指(趾)甲未见异常。口腔黏膜未见损害。皮损组织病理示:表皮部分增厚,表皮下见裂隙;真皮浅层乳头完整,浅层小血管增多,血管周围个别嗜酸性粒细胞和少量淋巴细胞,毛囊上皮细胞水肿,周围见少量淋巴细胞。直接免疫荧光:IgG、IgM、IgA、C3均(-)。诊断:痒疹样营养不良型大疱性表皮松解症。
作者 沈伟钦 薛汝增 潘慧清 谷梅
机构地区 南方医科大学皮肤病医院
出处 《皮肤性病诊疗学杂志》 2018年第2期104-106,共3页 Journal of Diagnosis and Therapy on Dermato-venereology
关键词 痒疹样 大疱性表皮松解症 营养不良型
分类号 R758.59 [医药卫生—皮肤病学与性病学]
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  • 2Fine J D, Eady R A, Bauer E A, et al. The classification of inherited epidermolysis bullosa (EB): Report of the third international consensus meeting on diagnosis and classification of EB[J]. J Am Acda Dermatol, 2008, 58 (6) :931-950.
  • 3Christiano A M, Hoffman G G, Zhang X, et al. Strategy for identification of sequence variants in COL7A1 and a novel 2- bp deletion mutation in recessive dystrophic epidermolysis bullosa[J]. Hum Mutat, 1997, 10(5) :408-414.
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  • 6Kern J S, Gruninger G, Imsak R, et al. Forty-two novel COL7A1 mutations and the role of a frequent single nucleotide polymorphism in the MMP1 promoter in modulation of disease severity in a large European dystropic epidermolysis bullosa cohort [J]. Br J Dermatol, 2009, 161 (5):1089-1097.
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皮肤性病诊疗学杂志
2018年 第2期

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