血脂异常与子痫前期相关性的研究进展

子痫前期(Pre-eclampsia,PE)是妊娠期特有的疾病,全球发病率3%～5%,可引发孕产妇子痫抽搐、胎儿生长受限、多脏器功能损害等,是导致孕产妇和围产儿病死率最高的疾病之一。子痫前期时存在着血脂异常,尤其是高甘油三酯血症。高甘油三酯血症可引起血管内皮细胞损伤,是动脉粥样硬化时内皮细胞功能紊乱的重要标志。而血管内皮细胞损伤是子痫前期发病的中心环节,是子痫前期病理变化从胎盘局部向全身脏器扩展的载体,是母体血流动力学和各器官功能发生异常的直接原因。因此本文将对血脂异常与子痫前期的相关性研究作一综述。

Pre-eclampsia, a special disease in pregnancy, occurs in about 3% - 5% of global pregnancies, which can cause maternal eclampsia, fetal growth restriction and multiple organs dysfunction. Dyslipidemia in pre-eclampsia, especially hypertriglyceridemia, can lead to endothelial cells injury and is an important marker of endothelial dysfunction in atherosclerosis. The injury of vascular endothelial cells is a central part in the pathogenesis of preeclampsia, a carrier of pathological changes of pre-eclampsia extending from placenta to systemic organs, and immediately causes the abnormal maternal hemodynamics and organs dysfunction. Therefore, this article reviews the correlation between preeclampsia and dyslipidemia.