不同促排卵方案对多囊卵巢综合征不孕症患者治疗效果的临床研究

Clinical Research on the Effect of Different Ovulation Induction Programs on Infertile Women with Polycystic Ovary Syndrome

目的 研究不同促排卵方案对多囊卵巢综合征(polycystic ovary syndrome,PCOS)不孕症患者的治疗效果,从中寻求一种便捷、有效且并发症少的促排卵方案。方法 选取195例PCOS不孕症患者,将其随机分为A(克罗米芬组n=48)、B(来曲唑组n=50)、C(克罗米芬+来曲唑组n=47)、D(来曲唑+来曲唑组n=50)4组,观察4组之间的成熟卵泡数、HCG日子宫内膜厚度、排卵率、妊娠率以及早期流产率等。结果 A组成熟卵泡个数较B组多,差异有统计学意义(P<0.05),就排卵率、妊娠率而言,C组和D组分别较A组、B组高,差异均有统计学意义(P<0.05),C组及D组两者比较差异无统计学意义(P>0.05),而早期流产率各组之间差异无统计学意义(P=0.73)。结论 来曲唑+来曲唑方案也能够相对提高PCOS不孕症患者的妊娠率及排卵率,为促排卵方案提供了一个新选择。

Objective To investigate the safety and efficacy of different ovulation induction protocols on infertile women with polycystic ovarian syndrome（PCOS）. Methods 195 infertile patients with PCOS were randomized into four groups. Group A（n = 48） received clomiphene（CC）,group B（n = 50） received letrozole（LE）,group C（n = 47） received CC ＋ LE,and group D（n = 50） received LE ＋ LE. The number of mature follicles,endometrial thickness on HCG day,ovulation rate,pregnancy rate,and early abortion rate were recorded and compared. Results The number of mature follicles in group A was higher than that in group B,and the difference was statistically significant（P〈0.05）. As for ovulation rate and pregnancy rate,the differences between group A and group C,group D,group B and group C,group D all have statistical meanings（P〈0.05）,while the difference between group C and goup D don,t（P〈0.05）. There was no statistically significant difference in the early abortion rate among all groups（P = 0.73）. Conclusion Letrozole ＋letrozole can improve the ovulation rate and pregnancy rate of infertile patients with PCOS. This may be an alternative option for ovulation induction.