新诊断2型糖尿病患者血清Omentin-1、IL-18水平变化与胰岛素抵抗的关系研究

Study of the Relationship Between the Changes of Serum Omentin-1,IL-18 Levels and Insulin Resistance in Patients Newly Diagnosed with Type 2 Diabetes Mellitus

目的 探讨新诊断2型糖尿病患者血清Omentin-1、IL-18水平变化与IR的关系。方法 选取新诊断T2DM组60例,分为超重或肥胖组30例,非肥胖组30例,对照组30例,测定各组血清空腹血糖、糖化血红蛋白、空腹胰岛素、甘油三酯等指标及Omentin-1、IL-18的水平。结果 Omentin-1与空腹血糖、糖化血红蛋白、空腹胰岛素、甘油三酯等指标呈负相关,IL-18与空腹血糖、糖化血红蛋白、空腹胰岛素、甘油三酯等指标呈正相关,均有统计学意义(P<0.05)。结论 Omentin-1、IL-18的水平变化与IR的发生发展密切相关。

Objective To investigate the relationship between the changes of serum Omentin-1,IL-18 levels and IR in patients newly diagnosed with type 2 diabetes mellitus. Methods 60 cases of newly diagnosed T2 DM group were divided into 30 cases of obese group and 30 cases of non-obese group. 30 cases were in the control group. The fasting blood glucose, glycosylated hemoglobin, fasting insulin, triglyceride and Omentin-1 and IL-18 of serum in these groups were measured. Results Omentin-1 was negatively correlated with fasting blood glucose, glycosylated hemoglobin, fasting insulin, triglyceride of serum, and IL-18 was positively correlated with fasting blood glucose, glycosylated hemoglobin, fasting insulin, triglyceride of serum. All of these are statistically significant（ P0. 05）. Conclusion The changes of Omentin-1 and IL-18 are closely related to the development of IR.