野木瓜茎枝三萜皂苷类化学成分研究

Chemical Constituents of Triterpenoid Saponins from Stem and Branches of Stauntonia chinensis

目的:研究野木瓜茎枝三萜皂苷类化学成分。方法:采用硅胶、ODS、葡聚糖凝胶(Sephadex LH-20)柱色谱、高效制备液相色谱等方法进行分离纯化,根据理化常数测定及波谱数据分析鉴定化合物结构。结果:从野木瓜茎枝中分离得到11个三萜皂苷类化合物,分别鉴定为:野木瓜苷YM30(1),野木瓜苷YM23(2),野木瓜苷YM12(3),野木瓜苷YM14(4),野木瓜苷YM25(5),3-O-α-L-吡喃鼠李糖基-(1→2)-α-L-吡喃阿拉伯糖基-30-降常春藤皂苷元-28-O-α-L-吡喃鼠李糖基-(1→4)-β-D-吡喃葡萄糖基-(1→6)-β-D-吡喃葡萄糖基酯苷(6),野木瓜苷YM8(7),3β,20α,24-三羟基-29-降齐墩果-12-烯-28-羧酸-23-O-β-D-吡喃葡萄糖苷(8),3β,20α,24-三羟基-29-降齐墩果-12-烯-28-羧酸-23-O-β-D-吡喃海藻糖基-(1→2)-[α-L-吡喃阿拉伯糖基-(1→4)]-β-D-吡喃葡萄糖苷(9),3-O-β-D-吡喃木糖基齐墩果酸-28-O-α-L-吡喃鼠李糖基-(1→4)-β-D-吡喃葡萄糖基-(1→6)-β-D-吡喃葡萄糖基酯苷(10),3-O-β-D-吡喃葡萄糖基-(1→4)-β-D-吡喃木糖基-(1→3)-α-L-吡喃鼠李糖基-(1→2)-α-L-吡喃阿拉伯糖基齐墩果酸-28-O-β-D-吡喃葡萄糖基-(1→6)-β-D-吡喃葡萄糖苷(11)。结论:化合物8~11为首次从该植物中分离得到。

Objective： To study the chemical constituents of triterpenoid saponins from the stem and branches of Stauntonia chinensis. Methods： The chemical constituents were isolated and purified by column chromatographies on silica gel,ODS,Sephadex LH-20 and MPLC. Their structures were elucidated on the basis of physicochemical properties and spectral analysis. Results： Eleven compounds were isolated from the stem and branches of S. chinensis and their structures were elucidated as yemuoside YM30（1）,yemuoside YM23（2）,yemuoside YM12（3）,yemuoside YM14（4）,yemuoside YM25（5）,3-O-α-L-rhamnopyranosyl-（1 → 2）-α-L-arabinopyranosyl-30-norhederagenin-28-O-α-L-rhamnopyranosyl-（ 1 → 4）-β-D-glucopyranosyl-（1→6）-β-D-glucopyranosyl ester（6）,yemuoside YM8（7）,3β,20α,24-trihydroxy-29-norolean-12-en-28-oic acid-23-O-β-D-glucopyranoside（8）,3β,20α,24-trihydroxy-29-norolean-12-en-28-oic acid-23-O-β-D-fucopyranosyl-（1 →2）-[α-L-arabinopyranosyl-（1 → 4）]-β-D-glucopyranoside（ 9）,3-O-β-D-xylopyranosyloleanolic acid-28-O-α-L-rhamnopyranosyl-（ 1 →4）-β-D-glucopyranosyl-（1→6）-β-D-glucopyranosyl ester（10）,3-O-β-D-glucopyranosyl-（1→4）-β-D-xylopyranosyl-（1 →3）-α-L-rhamnopyranosyl-（ 1 → 2）-α-L-arabinopyranosyloleanolic acid-28-O-β-D-glucopyranosyl-（ 1 → 6）-β-D-glucopyranoside（11）. Conclusion： Compounds 8-11 were isolated from this plant for the first time.