超声在新生儿胼胝体发育不全中的诊断价值

Diagnostic Value of Ultrasound in Neonatal Corpus Callosum Dysplasia

目的:探讨超声在诊断新生儿胼胝体发育不全中的价值。方法:2013年1月~2018年1月在新生儿重症监护室接受治疗的17 235例患儿,经超声检查检出确诊或可疑胼胝体发育不全64例,并以MRI检查结果为金标准,评估超声检查在胼胝体发育不全筛查中的准确性。结果:64例患儿经超声检查显示,28例为完全胼胝体发育不全,33例为部分胼胝体发育不全。以MRI为金标准,超声对完全胼胝体发育不全的诊断敏感性为100%,对部分胼胝体发育不全的诊断敏感性为88.9%,对完全胼胝体发育不全以及部分胼胝体发育不全的诊断特异性为92.3%和96.4%,准确性分别为89.1%和92.2%,Kappa值为0.796,P=0.000,二者的一致率为90%。结论:颅脑超声和MRI在新生儿胼胝体发育不全的诊断中均有较高价值,且颅脑超声无创、简便、经济实惠,便于临床普及,在新生儿胼胝体发育不全诊断中具有较高的应用价值。

Objective： To investigate the value of ultrasound in the diagnosis of the dysplasia of the corpus callosum of the newborn. Methods： The clinical data of 17,235 infants who were treated in neonatal intensive care unit from January,2013 to January,2018 were analyzed. Sixty-four cases of confirmed or suspected dysplasia of corpus callosum were diagnosed by ultrasound. The accuracy of ultrasound in the screening of corpus callosum dysplasia was evaluated by MRI which was adopted as the gold standard. Results： The results of ultrasound examination in 64 children showed that 28 cases were complete callosal agenesis,and 33 cases were partial callosum dysplasia. With MRI as the gold standard,the sensitivity of ultrasound for the diagnosis of complete corpus callosum hypoplasia was 100 and 88. 9% for partial dysplasia of corpus callosum. The diagnostic specificity of complete dysplasia of corpus callosum and partial dysplasia of corpus callosum were 92. 3% and 96. 4 respectively,the accuracy were 89. 1% and 92. 2%,and the Kappa value was 0. 796,P =0. 000. The consistent rate of the two methods was 90%. Conclusion： Both craniocerebral ultrasound and MRI are of high value in the diagnosis of neonatal corpus callosum dysplasia. Craniocerebral ultrasound is noninvasive,simple,economical and convenient for clinical popularization,and has a high application value in the diagnosis of neonatal corpus callosum dysplasia.