回顾与展望：特发性间质性肺炎的临床研究

Review and Prospect of Clinical Research on Idiopathic Interstitial Pneumonias

特发性间质性肺炎(idiopathic interstitial pneumonia,IIP)是一组原因不明的弥漫性实质性肺疾病,主要累及肺间质。随着对IIP研究的不断深入,IIP相关分类和治疗方案也经历了不断演变的过程。本文系统回顾IIP分类变迁、特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)急性加重概念演变以及不同时期IPF治疗方案出台的背景和最新进展,并对今后IIP的分类、诊断和治疗前景进行展望。

Idiopathic interstitial pneumonias（ ⅡPs） are a group of heterogeneous diffuse parenchymal lung diseases of unknown etiology,which mainly involve the interstitium of the lung. With the deepening of research,the classification and treatment of ⅡPs have gone through a process of continuous evolution.This article reviewed the changes in the classification of ⅡPs,the evolution of the concept and definition of acute exacerbation of idiopathic pulmonary fibrosis,and the background and latest progress in the treatment plan at different periods of IPF. We also prospected the classification,diagnosis,and treatment of ⅡPs in the future.