影响特发性肺纤维化治疗和预后的常见合并症

Common Comorbidities in Patients with Idiopathic Pulmonary Fibrosis

特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一种慢性进展性致纤维化性疾病,预后极差。IPF以中老年男性多见,容易出现多种临床合并症,包括肺气肿、肺癌、心血管疾病等。存在合并症的IPF患者临床症状更多、预后更差。本文详细阐述影响特发性肺纤维化治疗和预后的常见合并症,以期提高临床对于IPF合并症的认识和诊疗水平,从而改善IPF患者的生活质量及预后。

Idiopathic pulmonary fibrosis（ IPF） is a progressive fatal disease of the lung with unknown etiology and limited treatment options. It is more common in men and the elderly aged over 50 years,which also have a high incidence of emphysema,lung neoplasms,and cardiovascular disease. IPF patients with comorbidities often have a worse prognosis than those with IPF alone. We write this article in reference to common comorbidities in patients with idiopathic pulmonary fibrosis to draw physicians＇ attention. Clinical physicians should know that much can be done to identify and alleviate symptoms of those comorbidities,and to potentially improve the overall quality of life of these patients.