右美托咪定预防经尿道前列腺电切术后老年患者认知障碍的临床效果

Clinical effects of Dexmedetomidine in prevention of postoperative cognitive impairment of elderly patients with transurethral prostate resection

目的:观察右美托咪定预防经尿道前列腺电切术后老年患者认知障碍的临床效果。方法:选取行经尿道前列腺电切术后老年患者114例,采用随机数字表法分为两组,对照组患者57例采用咪达唑仑治疗,观察组患者57例采用右美托咪定治疗,于不同时间点行炎性因子水平检测和MMSE评分,比较两组患者麻醉效果、并发症情况。结果:观察组患者术后1 d、3 d时MMSE评分高于对照组(P<0.05),术后1 d、3 d、7 d时C反应蛋白、白介素-6、肿瘤坏死因子α、S-100β水平低于对照组(P<0.05),自主呼吸恢复时间、睁眼时间、言语陈述时间、定向力恢复时间早于对照组(P<0.05),并发症发生率低于对照组(P<0.05)。结论:右美托咪定预防经尿道前列腺电切术后老年患者认知障碍的临床效果优于咪达唑仑预防效果。

Objective： To investigate clinical effects of Dexmedetomidine in prevention of postoperative cognitive impairment of elderly patients with transurethral prostate resection. Methods： 114 elderly patients with transurethral prostate resection were selected and divided into two groups by the random number table method. 57 patients treated Midazolam were used as control group,while another 57 patients treated by Dexmedetomidine were chosen as observation group. Inflammatory factors and MMSE score were measured at different time points. The anesthetic effect and complications were compared between two groups. Results： The MMSE scores at 1 and 3 days after the operation in observation group were higher than those in the control group（ P〈0. 05）. The levels of C-reactive protein,interleukin-6,tumor necrosis factor α,and S-100β 1,3 and 7 days after the operation in observation group were lower than those in the control group（ P〈0.05）. The recovery time of spontaneous breathing,eye opening time,speech presentation time,and recovery time of directional force in observation group were earlier than those in the control group（ P〈0.05）. The incidence of complications in observation group was lower than that in the control group（ P〈0. 05）. Conclusions： Dexmedetomidine in the prevention of postoperative cognitive impairment of the elderly patients with transurethral prostate resection is more effective than Midazolam.