三阴性乳腺癌中TOPOⅡα表达以及预后关系研究

Expression and Prognostic Significance of TopoⅡα in Triple Negative Breast Cancer

目的探讨拓扑异构酶Ⅱα(topoisomeraseⅡα,TopoⅡα)表达与三阴性乳腺癌发生发展及预后的关系。方法应用SABC免疫组化法,检测186例三阴性乳腺癌(包括165例浸润性导管癌和21例导管原位癌)中TopoⅡα蛋白的表达水平。结果 TopoⅡα在浸润性导管癌组织以及导管原位癌组织中阳性表达率分别为73.9%和47.6%,TopoⅡα在有淋巴结转移者中阳性表达率高达80.9%,显著高于无淋巴结转移者(49.6%),两者相比差异具有统计学意义。TopoⅡα表达与患者年龄、肿瘤大小和临床分期以及组织学分级无关。结论 TopoⅡα的表达在三阴性乳腺癌的发生发展中扮演着重要的促进角色,也与有无淋巴结转移息息相关。

Objective To study the relationship between the expression of topoisomerase II alpha（topoisomerase II alpha,TopoⅡα） and the occurrence,development and prognosis of triple negative breast cancer. Methods the expression level of TopoⅡα protein was detected by SABC immunohistochemistry in 186 cases of triple negative breast cancer,including 165 cases of invasive ductal carcinoma and 21 cases of carcinoma in situ. Results the positive rate of TopoⅡαexpression in invasive ductal carcinoma tissues and the original parts were as follows：73. 9% and 47. 6%,Topo Ⅱα in patients with lymph node metastasis positive rate was 80. 9%,which was significantly higher than that without lymph node metastasis,49. 6%,the difference was statistically significant. The expression of TopoⅡα was not related to age,tumor size,stage and histological grade. Conclusion The expression of TopoⅡα plays an important role in the occurrence and development of triple negative breast cancer,and it is closely related to the existance of is lymph node metastasis.