增强CT扫描联合肿瘤标志物检测对非小细胞肺癌的诊断价值

Diagnostic Value of Enhanced CT Scan Combined with Tumor Marker Detection in Non-small Cell Lung Cancer

目的综合分析增强CT扫描联合肿瘤标志物(细胞角蛋白19、癌胚抗原和p53抗体)检测对非小细胞肺癌的诊断效果及应用价值。方法选取153例非小细胞肺癌患者作为研究对象,按照入院顺序随机分为增强CT扫描组、肿瘤标志物组和联合组,每组均为51例。增强CT扫描组应用西门子64排螺旋CT机的诊断方法、肿瘤标志物组应用在手术或者化疗之前检测患者的细胞角蛋白19、癌胚抗原和p53抗体等诊断方法,联合组应用增强CT扫描联合肿瘤标志物检测的诊断方法。采用SPSS20.0统计学软件进行统计学分析3组非小细胞肺癌患者的敏感度、特异度、阴性预测值、与病理检查结果的符合率和阳性预测值等参数指标。结果 (1)联合组非小细胞肺癌患者的敏感度、特异度、阴性预测值、与病理检查结果的符合率和阳性预测值显著高于增强CT扫描组、肿瘤标志物组,3组数据比较差异有统计学意义(P<0.05);(2)增强CT扫描组、肿瘤标志物组单独检测非小细胞肺癌患者的敏感度、特异度、阴性预测值、与病理检查结果的符合率和阳性预测值比较,差异无统计学意义(P>0.05);(3)增强前后非小细胞肺癌患者的平均CT值比较,有统计学差异(P<0.05)。结论增强CT扫描联合肿瘤标志物检测对非小细胞肺癌的诊断效果及应用价值显著。

Objective To evaluate the value of enhanced CT scan combined with tumor markers（cytokeratin 19,carcinoembryonic antigen and p53 antibody） in the diagnosis of non-small cell lung cancer. Methods 153 patients with non-small cell lung cancer were randomly divided into 3 groups：enhanced CT scan group,tumor marker group and combined group each with 51 cases. The CT scan group used CT to diagnose the cytokeratin 19,carcinoembryonic antigen and p53 antibody in the patients before surgery or chemotherapy. The combined group was treated with enhanced CT scan diagnostic method of tumor marker detection. SPSS 20. 0 statistical software was used to analyze the sensitivity,specificity,negative predictive value,coincidence rate and positive predictive value of the 3 groups of non-small cell lung cancer（ NSCLC）. Results（1） The coincidence rate and positive predictive value of the combined sensitivity,specificity and negative predictive value of the combined group were significantly higher than those of the enhanced CT scan group and the tumor marker group,and the difference between the 3 groups（ P〈0. 05）.（2） The sensitivity,specificity and negative predictive value of CT scan group and tumor marker group were compared with those of non-small cell lung cancer（ NSCLC）,and the coincidence rate and positive predictive value of pathologic examination were compared（ P〉0. 05）.（3） The mean CT value of patients with non-small cell lung cancer before and after enhancement was statistically significant（ P〈0. 05）. Conclusion Enhanced CT scan combined with tumor markers in the diagnosis of non-small cell lung cancer has significant application value.