食道癌伴抑郁患者脑电频率变化与额叶认知功能损害关联研究

Study on the relationship between change of brain electrical frequency and cognitive functional impairment in patients with esophageal cancer and depression

目的探讨食道癌伴抑郁患者脑电频率变化和额叶认知功能损害的关系。方法对60例食道癌伴抑郁患者(研究组)和60例正常对照组进行额叶认知功能评定和脑电图检查,同时研究组分为有和无精神病性症状组(PD组和NPD组),采用贝克抑郁自评量表(Beck抑郁量表)和简明精神病量表(BPRS)评估患者的临床症状。结果 (1)研究组和PD组分别与对照组相比,Stroop测验、数字颜色连线得分均显著延长,言语流畅性成绩均显著减小;NPD与对照组相比,Stroop测验、数字颜色连线得分均显著延长;PD组与NPD相比,Stroop测验、数字颜色连线得分显著延长。(2)研究组前额脑波α1、δ、θ功率均显著高于对照组;用多因素方差分析对研究组与对照组左右前额脑波功率进行比较,发现α1差异有统计学意义。(3)控制Beck抑郁评分后,研究组左前额α1波和θ波功率与言语流畅性得分负相关,与数字颜色连线、Stroop测验均正相关。结论前额脑电功率变化与食道癌伴抑郁患者额叶认知功能损害相关。

Objective To investigate the relationship between changes of electroencephalogram frequency and cognitive dysfunction in patients with esophageal cancer and depression.Methods A total of 60 patients with esophageal cancer complicated with depression were recruited in the study group and 60 normal controls were assessed for cognitive function of the frontal lobe and electroencephalogram（ECG）.The study group was subdivided into with and without psychotic symptoms（PD and NPD groups）.Beck＇s Depressive Self-Rating Scale（Beck Depression Scale） and Concise Psychiatric Inventory（BPRS） were used to assess the patient ＇s clinical symptoms.Results Compared with the control group,the Stroop test and the number of color connection scores in the study group and the PD group were significantly prolonged,and the verbal fluency scores were significantly reduced.Compared with the control group,the Stroop test and digital color connection scores were prolonged in the NPD group.Compared with NPD group,the above indicators in PD group were significantly prolonged.The power of the forehead brainwaves α1,δ and θ in the study group was significantly higher than that in the control group.The multivariate analysis revealed that the power of α1 showed a significant difference in left and right forehead brainwave powers between the study group and the control group.After controlling the Beck depression score,the left frontal α1 wave and θwave power of the study group were negatively correlated with the verbal fluency score,and positively correlated with the digital color connection and the Stroop test.Conclusion The change of prefrontal brain electrical power is related to cognitive impairment in patients with esophageal cancer and depression.