血必净注射液、生长抑素单药及联合用药对急性重症胰腺炎的炎症改善及预后的影响

Effect of Xuebijing injection,somatostatin monotherapy and their combined therapy on inflammation and prognosis in acute severe acute pancreatitis

目的探讨血必净注射液、生长抑素单药及联合用药对急性重症胰腺炎的炎症改善及预后的影响。方法选取90例急性重症胰腺炎患者,根据治疗方案分成A组、B组、C组各30例。A组采用单独的血必净注射液治疗,B组采用单独的生长抑素治疗,C组采用血必净注射液、生长抑素联合治疗,均持续治疗7 d。对比3组患者临床症状缓解时间及治疗前后炎症、预后改善效果。结果 C组患者的肛门排便恢复时间、腹痛缓解时间、肠鸣音恢复时间、腹胀缓解时间均显著低于A组、B组(P<0.05);治疗后3组患者的炎症指标白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平均显著低于治疗前,且C组显著低于A组、B组(P<0.05);治疗后3组患者的预后APACHE-Ⅱ评分均显著低于治疗前,且C组显著低于A组、B组(P<0.05)。结论血必净注射液、生长抑素联合治疗急性重症胰腺炎效果显著优于单药治疗,能提高炎症改善效果,改善预后。

Objective To study the effects of Xuebijing injection,somatostatin monotherapy and their combination therapy on the improvement of inflammation and prognosis in acute severe pancreatitis.Methods A total of 90 patients with acute severe pancreatitis treated in our hospital were enrolled in this study.Patients were divided into group A,group B and group C,with 30 cases in each group.The patients in group A were treated with Xuebijing injection alone,and the patients in group B were treated with somatostatin alone,and patients in group C were treated with Xuebijing injection and somatostatin,and all the treatment was lasted for 7 days.The alleviation time of clinical symptoms,improvement of inflammation and prognosis in three groups before and after treatment were observed and compared.Results After treatment,the anal defecation recovery time,abdominal pain relief time,bowel sounds recovery time and abdominal distension time in the three groups were lower than treatment before,and group C were lower than group A and group B（P〈0.05）.The levels of interleukin-6（IL-6）,tumour necrosis factor-α（TNF-α） and C-reactive protein（CRP） were significantly lower in group C than those in group A and group B（P〈0.05）.The APACHE-Ⅱscores after treatment was higher than treatment before,and C group was lower than A group,B group（P〈0.05）.Conclusion Xuebijing injection in combined with somatostatin for acute severe pancreatitis has significantly better efficacy than monotherapy,and it can improve the efficacy of inflammation treatment,and prognosis.