康柏西普联合手术治疗新生血管性青光眼的疗效评价

Effect of conbercept combined with operation on treatment of patients with neovascular glaucoma

目的探讨康柏西普联合手术治疗新生血管性青光眼的临床疗效。方法选取新生血管性青光眼患者10例(10眼),随机分为2组,实验组予以康柏西普玻璃体腔内注射联合小切除以及全视网膜激光光凝术(PRP)治疗,对照组采用阿托品等药物联合外科手术常规治疗。比较2组疗效、眼压变化、视力改善、房水中血管内皮生长因子(VEGF)表达水平。结果2组患者治疗后视力均明显提升。2组患者治疗前后眼压显著明显(P<0.05)。2组血清以及房水中VEGF表达水平均显著降低,且实验组VEGF下降水平显著更低(P<0.05)。结论康柏西普结合外科手术可以有效改善新生血管性青光眼患者临床症状,降低眼压。

Objective To explore the effect of conbercept combined with operation on treatment of patients with neovascular glaucoma.Methods A total of 10 patients with neovascular glaucoma（10 eyes） were selected and randomly divided into experimental group and control group.The experimental group was treated with intravitreal injection of conbercept plus trabeculectomy and panretinal photocoagulation（PRP）,while the control group was treated with atropine,glucocorticoid and panretinal photocoatulation.The pre-treatment and post-treatment visual acuity,intraocular pressure and vascular endothelial growth factor（VEGF） expression in serum and humor aqueous were compared.Results After treatment,the visual acuity improved significantly（P〈0.05）.The intraocular pressure of the experimental group and control group before treatment and after treatment decreased significantly（P〈0.05）.The expression level of the post-treatment VEGF in serum and humor aqueous in the experimental group and control group decreased significantly,and the level of VEGF experimental group was much more lower（P〈0.05）.Conclusion Application of conbercept combined with surgery can effectively improve the clinical symptoms and reduce intraocular pressure in patients with neovascular glaucoma.