磁共振功能性成像用于胶质瘤术前术中的研究进展

Progress of preoperative and intraoperative MR functional imaging in glioma

脑胶质瘤是最常见原发脑内肿瘤,起源于神经胶质细胞,以局部侵袭性生长为特征。MRI是诊断脑胶质瘤的主要影像手段。随着MR波谱成像(MR spectroscopy,MRS)、扩散张量成像(diffusion tensor imaging,DTI)和血氧水平依赖性功能磁共振成像(blood oxygen level-dependent functional magnetic resonance imaging,BOLD-f MRI)等功能MRI的发展,对于以手术为主的胶质瘤,能进行个性化的术前规划和术中监测,从而降低术后损伤,改善预后。作者就MRI及MRS、DTI、BOLD-f MRI这三种功能成像对胶质瘤术前规划和术中监测及存在的问题进行综述。

Brain glioma is the most common primary brain tumor, originated from glial cells and characterized by local invasive growth. MR is the main imaging method for diagnosis of glioma. With the development of MR Spectroscopy （MRS）, diffusion tensor imaging （DTI） and blood oxygen level-dependent functional magnetic resonance imaging （BOLD-fMRI）. It could reduce postoperative injury and improve the prognosis for gliomas which surgery was the main treatment by personalized preoperative planning and intraoperative monitoring. In this paper, the use of normal MRI and functional MR including MRS, DTI and BOLD-fMRI in preoperative planning and intraoperative monitoring of glioma was reviewed.