大肠埃希菌、阴沟肠杆菌和肺炎克雷伯菌耐药率与抗菌药物使用的相关性分析

Analysis on the correlation between resistance rates of Escherichia coli,Enterobacter cloacae,Klebsiella pneumoniae and antibiotic usage

目的分析该院2014年肠杆菌科细菌分离率居前三位细菌的耐药率与抗菌药物使用的相关性,指导临床合理地使用抗菌药物。方法通过Whonet5.6软件统计2014年该院大肠埃希菌、阴沟肠杆菌和肺炎克雷伯菌的耐药率,同时统计抗菌药物的用药频度(DDDs)值,将耐药率和DDDs进行相关性分析。结果肺炎克雷伯菌和阴沟肠杆菌对碳青霉烯类抗菌药物的耐药率与其使用量呈正相关(均P<0.05)。结论肺炎克雷伯菌和阴沟肠杆菌对碳青霉烯类抗菌药物的耐药率与碳青霉烯类药物的使用量呈正相关,应建议临床使用抗菌药物治疗时,合理、有效减少细菌耐药株的出现。

Objective To analyze the correlation between the resistance rates of Escherichia coli,Enterobacter cloacae,Klebsiella pneumoniae and the antibiotic usage,so as to guide clinical reasonable use of antibacterials.Methods Resistance rates of Escherichia coli,Enterobacter cloacae,Klebsiella pneumoniae were summarized by Whonet5.6 software,and the antibacterial agent consumption which were calculated by using defined daily doses（DDD）were summarized by Pharmaceutical Department during 2014,then their correlation were analyzed.Results Klebsiella pneumoniae and Enterobacter cloacae showed their resistance positively correlated with the consumption of carbapenem（P〈0.05）.Conclusion As resistance rates of Klebsiella pneumoniae and Enterobacter cloacae are relative to the use of antibacterials in some degree,antibacterials should be reasonably chosen so as to reduce occurrence of drug resistant strains.