脓毒症患者血清降钙素原表达及其对预后的影响分析

The expression of serum procalcitonin in sepsis patients and its influence on prognosis

目的探讨脓毒症患者血清降钙素原表达及其对预后的影响。方法选自该院于2014年12月至2016年12月期间收治的脓毒症患者119例,按照病情严重程度范围早期脓毒症组49例、严重脓毒症组37例、脓毒症休克组33例。按照患者入院后28d预后分为存活组95例和死亡组24例。采用双抗体夹心酶标免疫分析法测定血清降钙素原。比较各组白细胞计数、C反应蛋白和APACHEⅡ评分、血清降钙素原水平变化,及存活组和死亡组血清降钙素原水平变化。结果脓毒症休克组白细胞计数、C反应蛋白和APACHEⅡ评分高于早期脓毒症组和严重脓毒症组(P<0.05);严重脓毒症组白细胞计数、C反应蛋白和APACHEⅡ评分高于早期脓毒症组(P<0.05)。脓毒症休克组血清降钙素原水平高于早期脓毒症组和严重脓毒症组(t分别为33.136、21.863,P<0.05);严重脓毒症组血清降钙素原水平高于早期脓毒症组(t=16.876,P<0.05)。死亡组血清降钙素原水平高于存活组(P<0.05)。结论脓毒症患者血清降钙素原水平明显上升,随着病情严重血清降钙素原水平越高,且可作为预后评估的一项指标。

Objective To investigate the expression of serum procalcitonin in patients with sepsis and its influence on prognosis.Methods From December 2014 to December 2016,119 cases of sepsis patients were enrolled in the hospital.According to the severity of the disease,49 cases in the early sepsis group,37 cases in the severe sepsis group and 33 cases in the septic shock group.According to the prognosis of 28 dafter admission,the patients were divided into the survival group（95 cases）and the death group（24 cases）.Serum procalcitonin was measured by double antibody sandwich enzyme-linked immunosorbent assay.The changes of WBC count,C reactive protein and APACHE Ⅱ score,serum procalcitonin level,serum procalcitonin level and survival group and death group were compared.Results Septic shock of white blood cell count,C reaction protein and APACHEⅡ were higher than those of early sepsis group and severe sepsis group（P〈0.05）;severe sepsis group cell counts,C reactive protein and APACHE Ⅱ were higher than those of early sepsis group（P〈0.05）.The septic shock group of serum procalcitonin levels higher than the early sepsis group,severe sepsis group（t=33.136,21.863,P〈0.05）;severe sepsis group serum procalcitonin levels higher than the early sepsis group（t=16.876,P〈0.05）.The level of serum procalcitonin in the death group was higher than that in the survival group（P〈0.05）.Conclusion The level of serum procalcitonin in patients with sepsis is obviously higher.With the severity of the disease,the serum procalcitonin level is higher,and can be used as an indicator of prognosis evaluation.