重症肺炎链球菌感染患儿血清TNF-α、IL-1β、IL-6的表达水平及意义

Serum TNF-α,IL-1β and IL-6 expression levels and significance of children with severe pneumococcal infection

目的探讨重症肺炎链球菌感染患儿血清肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)、白细胞介素6(IL-6)表达水平及临床意义。方法选取2016年1月至2017年1月该院收治的37例重症肺炎链球菌感染患儿(重症感染组)及36例普通肺炎链球菌感染患儿(普通感染组)为研究对象,同期选取37例健康小儿为对照,检测所有儿童免疫球蛋白IgA、IgM、IgG水平和血清中TNF-α、IL-1β、IL-6表达水平。结果重症感染组、普通感染组CD3^+、CD4^+、CD4^+/CD8^+、IgA、IgG水平明显低于对照组(P<0.05);重症感染组血清TNF-α、IL-1β、IL-6水平明显高于普通肺炎组及对照组,且普通肺炎组高于对照组(P<0.05);重症感染组急性期血清TNF-α、IL-1β、IL-6水平明显高于同组恢复期及普通肺炎链球菌急性期水平,且普通肺炎链球菌急性期水平明显高于同组恢复期(P<0.05),重症感染组恢复期IL-1β水平明显高于普通肺炎链球菌恢复期及对照组(P<0.05)。结论重症肺炎链球菌感染患儿存在免疫功能紊乱,血清TNF-α、IL-1β、IL-6水平明显升高,三者可作为评估重症肺炎链球菌感染严重程度的参考指标。

Objective To explore serum tumor necrosis factor-α（TNF-α）,interleukin 1β（IL-1β）,interleukin 6（IL-6）expression levels and clinical significance of children with severe pneumococcal infection.Methods 37 cases of children with severe Streptococcus pneumococcal infection（severe infection group）and 36 cases with normal Streptococcus pneumoniae infection（normal infection group）treated in our hospital from January 2016 to January 2017 were enrolled as the study objects,and 37 cases of healthy children were enrolled as the control group in the same period.The levels of immunoglobulin IgA,IgM,IgG and the levels of TNF-,IL-1 and IL-6 in the serum of all children were detected.Results CD3^＋,CD4^＋,CD4^＋/CD8^＋,IgA and IgG levels in the severe infection group,the normal infection group were significantly lower than those of the control group（P〈0.05）.Serum TNF-α,IL-1βand IL-6 levels in the severe infection group were significantly higher than those in the normal infection group,and the normal infection group were higher than the control group（P〈0.05）.Serum TNF-α,IL-1β and IL-6 levels in acute period of the severe infection group were significantly higher than those in recovery period of the same group and same period of the normal infection group,and the acute period were higher than in recovery period of the same group（P〈0.05）.IL-1β level in recovery period of the severe infection group were significantly higher than that in recovery period of the normal infection group and the control group（P〈0.05）.Conclusion Children with severe pneumococcal infection have immune dysfunction,and serum TNF-α,IL-1β,IL-6 levels significantly increased.These data suggest that the three can be used as a reference marker for assessing the severity of severe pneumococcal infections.