IL-6、IL-26在胃癌患者中的变化及其临床意义

Changes of serum IL-6 and IL-26 concentrations in patients with gastric cancer and its clinical significance

目的探讨白细胞介素(IL)-6、IL-26在胃癌患者血清中的变化及其临床意义。方法选取收治时间2014年1月至2015年1月经病理学确诊的胃癌患者80例作为胃癌组,同期体检健康人群80例作为对照组,采用ELISA方法检测两组血清IL-6、IL-26的水平,并分析这两项指标与胃癌患者的临床病理学特征的关系。结果胃癌组患者的血清IL-6、IL-26的水平高于对照组,差异具有统计学意义(P<0.05);发生淋巴结转移的胃癌患者、TNM分期Ⅲ~Ⅳ期的胃癌患者血清IL-6分别高于未发生淋巴结转移的胃癌患者和TNM分期为Ⅰ~Ⅱ期的胃癌患者(P<0.05);发生淋巴结转移的胃癌患者、TNM分期Ⅲ~Ⅳ期的胃癌患者、肿瘤直径大于5cm的胃癌患者血清IL-26分别高于未发生淋巴结转移的胃癌患者、TNM分期为Ⅰ~Ⅱ期的胃癌患者和肿瘤直径小于或等于5cm的胃癌患者(P<0.05)。结论胃癌组患者的血清IL-6、IL-26的水平升高明显,并且与患者发生淋巴结转移、TNM分期、肿瘤增大有关。

Objective To investigate the changes of serum IL-6 and IL-26 concentrations in patients with gastric cancer and its clinical significance.Methods Selected 80 patients with pathologically confirmed gastric cancer（treated from January 2014 to January 2015）were enrolled as gastric cancer group,and 80 healthy people in the same period were enrolled as control group,the concentrations of serum IL-6 and IL-26 in two groups were measured by using ELISA,and the relationships between the two indexes and clinicopathological characteristics of gastric cancer patients were analyzed.Results The serum concentrations of IL-6 and IL-26 in the patients with gastric cancer were significantly higher than those in the control group,the difference was statistically significant（P〈0.05）.The serum IL-6 concentrations of the patients with gastric cancer with lymph node metastasis and TNM stageⅢ-Ⅳ were higher than those of gastric cancer patients without lymph node metastasis and TNM stageⅠ-Ⅱ（P〈0.5）.The serum IL-26 concentrations of gastric cancer patients with lymph node metastasis,TNM stageⅢ-Ⅳ and tumor diameter5 cm were higher than that of gastric cancer patients without lymph node metastasis,TNM stage Ⅰ-Ⅱ and with tumor diameter less than 5 cm（P〈0.05）.Conclusion The concentrations of serum IL-6 and IL-26 in patients with gastric cancer increased significantly,and were related to lymph node metastasis,high stage of TNM stage and tumor enlargement.