降钙素原和超敏C-反应蛋白变化在烧伤感染不同时期的意义

Significance of changes of procalcitonin and high sensitivity C-reactive protein in different stages of burn infection

目的研究烧伤感染患者血清降钙素原(PCT)和超敏C-反应蛋白(CRP)水平在烧伤感染期和感染好转期的意义。方法对2013年9月~2016年12月在我院烧伤科治疗的26例烧伤感染患者的临床资料进行回顾性分析。动态监测PCT和CRP水平的变化,分析其变化与烧伤感染、感染好转间的关系。结果感染好转期PCT及CRP水平与感染期比较有显著差异(P<0.01),其PCT及CRP水平较感染期显著降低,白细胞、中性粒细胞、血小板计数、ALT、血钠水平与感染期比较,差异无显著性(P>0.05)。结论烧伤感染患者PCT和CRP水平对烧伤感染、感染好转具有重要的判断价值,在烧伤感染治疗过程中具有重要的指导意义。

Objective To study the significance of serum procalcitonin（ PCT） and high sensitivity C-reactive protein（ CRP） levels in patients with burn infection during the period of burn infection and infection improvement.Methods A total of 26 patients with burn infection who were treated with burns in our hospital from September 2013 to December 2016 were retrospectively analyzed. The data were divided into two groups,respectively： infection data and infection remission data,dynamic monitoring of serum levels of procalcitonin and high sensitivity C-reactive protein changes,analysis of changes in the relationship between burn infection period and infection improvement period. Results There were significant differences in the levels of PCT and CRP in the period of infection,compared with the infection was improving（ P〈0. 01）,the PCT and CRP levels in the period of infection improvement were significantly lower than that in the infection period. There was no significant difference in the levels of white blood cells,neutrophils,platelet count,ALT and serum sodium between infection and infection was improving（ P〉0. 05）. Conclusion The levels of serum procalcitonin and high sensitivity C-reactive protein in burn infection patients have an important value to helping to judge the stage of burn is in infection or in improvement stage of infection. And it is of great guiding significance in the treatment of burn infection.