手足口病患儿血清hs-CRP、PCT水平和血气分析检测的临床意义

Changes of Serum hs-CRP,PCT Levels and Blood Gas Analysis in Children with Hand,Foot and Mouth Disease and Its Clinical Significance

目的:观察手足口病(HFMD)患儿超敏C反应蛋白(hs-CRP)、降钙素原(PCT)水平和血气分析结果的变化,探讨其临床意义。方法:将收治的102例HFMD患儿分为普通组(n=40)、重症组(n=35)和危重症组(n=27),另选择30例健康儿童为对照组。检测各组患儿血清hs-CRP、PCT水平和血气分析[动脉血氧分压(Pa O2)、动脉血二氧化碳分压(Pa CO2)、血乳酸(Lac)和酸碱度(p H)]指标。结果:经单因素方差分析(one-way ANOVA),四组患儿血清hs-CRP和PCT浓度比较差异有统计学意义(P<0.05);三组HFMD患儿血清hs-CRP和PCT浓度均高于对照组,差异有统计学意义(P<0.05);危重症组患儿血清hs-CRP和PCT浓度均高于其他各组,差异有统计学意义(P<0.05);重症组患儿血清hs-CRP和PCT浓度均高于普通组,差异有统计学意义(P<0.05)。危重症组患儿Pa O2和p H低于普通组和对照组,Pa CO2和Lac水平高于普通组和对照组,差异均有统计学意义(P<0.05);重症组患儿Pa O2和p H水平低于对照组,Pa CO2和Lac水平高于对照组,差异均有统计学意义(P<0.05);普通组Pa O2和p H水平略低于对照组,Pa CO2和Lac水平略高于对照组,但差异均无统计学意义(P>0.05)。结论:血清hs-CRP、PCT水平和血气分析指标与HFMD患儿病情严重程度存在相关性,可作为早期诊断HFMD的参考指标。

Objective： To observe the changes of hypersensitive C-reactive protein（ hs-CRP）,procalcitonin（ PCT） and blood gas analysis in children with hand,foot and mouth disease（ HFMD）,and to explore its clinical significance. Methods： A total of 102 children with HFMD were divided into three groups： normal group（ n = 40）,severe group（ n = 35）,critically ill group（ n = 27）,and another 30 healthy children as control group. Serum hs-CRP,PCT levels and blood gas analysis（ Pa O2,Pa CO2,Lac,p H） were measured in all subjects. Results： By one-way ANOVA,there were significant differences in serum hs-CRP and PCT levels between the four groups（ P〈0. 05）. The levels of serum hs-CRP and PCT in children with HFMD were significantly higher than those in the control group（ P〈0. 05）. The levels of serum hs-CRP and PCT in the critically ill group were higher than those in the other groups（ P〈0. 05）.The levels of serum hs-CRP and PCT in the severe group were higher than those in the normal group（ P〈0. 05）. Pa O2 and p H levels in the critically ill group were lower than those in the normal and control groups,and the levels of Pa CO2 and Lac were higher than those in the normal group and the control group,the differences were statistically significant（ P〈0. 05）. Pa O2 and p H in the severe group were lower than those in the control group,and the levels of Pa CO2 and Lac were higher than those in the control group,the differences were statistically significant（ P〈0. 05）. Pa O2 and p H were lower in the normal group than those in the control group,and the levels of Pa CO2 and Lac were slightly higher than those in the control group,but there were no significant differences between the two groups（ P〉0. 05）.Conclusion： Serum hs-CRP,PCT levels and blood gas analysis indicators are associated with the severity of HFMD children,which can be used as reference indicators for early diagnosis of HFMD.