消旋卡多曲颗粒联合布拉酵母菌散佐治小儿轮状病毒肠炎的疗效及其对免疫功能的影响

Racecadotril Granules and Saccharomyces Boulardii Sachets on Immune Function in Infants with Rotavirus Enteritis

目的:观察消旋卡多曲颗粒联合布拉酵母菌散对轮状病毒肠炎(RVE)患儿的临床疗效以及对患儿免疫调节作用。方法:选取2015年12月至2017年4月我院收治的RVE患儿136例,采用随机数字表法分为对照组和观察组各68例。对照组在对症治疗的基础上加用消旋卡多曲颗粒,观察组在对照组治疗的基础上加用布拉酵母菌散。采用酶联免疫吸附(ELISA)法测定白介素-17(IL-17)和白介素-10(IL-10)水平。结果:观察组退热时间、呕吐停止时间、腹泻停止时间分别为(2.34±0.54)d、(1.32±0.26)d、(2.56±0.42)d,均显著短于对照组的(3.53±0.56)d、(1.92±0.37)d、(3.49±0.64)d(P<0.05)。观察组临床治疗有效率为95.6%,显著高于对照组的82.4%(P<0.05)。两组患儿IL-17和IL-10治疗前表达差异均无统计学意义(P>0.05)。治疗后观察组IL-17显著高于对照组,IL-10显著低于对照组(P<0.01)。结论:消旋卡多曲颗粒联合布拉酵母菌散可显著降低轮状病毒肠炎患儿IL-17表达和升高IL-10表达,调节患儿免疫反应,显著提高临床疗效。

Objective： To observe the effect of racecadotril granules and saccharomyces boulardii sachets on immune function in infants with rotavirus enteritis（ RVE） and explore its clinical significance. Methods： One hundred and thirty-six cases of RVE children from Dec. 2015 to Apr. 2017 were selected in this study,which were randomly divided into control group（ n = 68） and observation group（ n = 68）. The control group was given racecadotril granules,the observation group was given saccharomyces boulardii sachets on the basis of control group. IL-17 and IL-10 were detected by ELISA analysis. Results： The defervescence time,vomiting and diarrhea stopping time were（ 2. 34±0. 54） d,（ 1. 32±0. 26） d,（ 2. 56±0. 42） d in observation group,which were significantly lower than those of（ 3. 53±0. 56） d,（ 1. 92±0. 37） d,（ 3. 49±0. 64） d in control group（ P〈0. 05）. The clinic effects rate was 95. 6% in observation group,which was higher than 82. 4% in control group（ P〈0. 05）. There was no significant difference of IL-17 and IL-10 expression between the two groups before treatment（ P〉0. 05）. After treatment,IL-17 was higher in observation group than that in control group（ P〈0. 01）,and IL-10 was lower in observation group than that in control group（ P 〈 0. 01）. Conclusion： Racecadotril granules and saccharomyces boulardii sachets can increase IL-17 and decrease IL-10 in RVE children,which regulated the immune response and increased the clinical efficacy.