转录因子KLF8基因结构及其功能研究进展

Research Progress on the Structure and Function of Transcription Factor KLF8 Gene

随着分子生物学研究的进展,机体各种生物学特性的影响都在分子水平上寻求到原因。转录因子作为调节基因转录的重要蛋白质,一直在被人们进行种类发掘及功能鉴定。KLF8（Krüppel-like factor 8）是属于KLFs（Krüppel-like factors）家族中的一种转录因子,对细胞侵袭和上皮-间质转化、细胞致癌性转化和肿瘤、细胞周期循环、脂肪细胞分化等方面有着深远影响。由于其在生物学功能上的多方面影响,使其逐渐成为科研人员探究的热点。对该转录因子的结构和作用已经有了深入的了解。现就KLF8基因与蛋白质的分子结构和生物学特性研究进展进行综述,可为该基因作为遗传标记奠定基础并以期为相关研究如癌症调控、肥胖治疗及基础研究等提供参考。

With the progress of molecular biology research, the influence of various biological characteristics of the organism seeks the reason at the molecular level. Transcription factors as the important protein regulate gene transcription,and they have been explore the types and functional identification. KLF8（ Krüppel-like factor 8） is a transcription factor belonging to the family of Krüppel-like factors（ KLFs）,which plays a significant role in cell invasion and epithelial-mesenchymal transition,cell carcinogenesis and tumor,cell cycle and adiposity differentiation. Due to its various biological functions,it gradually becomes a hot spot for researchers to explore. The structure and function of this transcription factor has been well understood. The research progress on the molecular structure and biological characteristics of KLF8 gene and protein are explained. The gene can be used as a genetic marker and provide a reference for related research such as cancer regulation,obesity treatment and basic research.