鼠痘病毒感染机制及其检测方法研究进展

Research Progress on Infection Mechanism and Diagnostic Methods of Ectromelia Virus

概述了鼠痘病毒(ECTV)入侵动物机体后感染传播的机制,包括小鼠的天然抗病机理、机体免疫应答以及病毒感染的致病机理等。同时总结了检测ECTV的试验动物法、病理学方法、血清学方法和核酸诊断方法等的优缺点。通过系统了解ECTV的感染途径和诊断方法 ,有助于防控ECTV的发生及传播。

The paper mainly reviewed the infection and spread mechanisms of Ectromelia virus （ECTV） in animals, including natural disease resistance mechanism of the mice, the body＇s immune response and pathogenic mechanism of virus infection. Furthermore, we described the animal experiments, pathologi- cal diagnosis, serological methods, nucleic acid methods of ECTV and their advantages and disadvantages. This article can help to understand infection mechanism and different diagnostic methods of ECTV, which may contribute to control the spread of ECTV.