基于脂多糖-Toll样受体4信号通路抗内毒素血症机制研究进展

Mechanism of anti-endotoxemia based on LPS-TLR4 signaling pathway:research advances

Toll样受体4(TLR4)是TLR家族中极为重要的成员,同时被认为是脂多糖(LPS)受体的编码基因,是识别LPS的主要受体,LPS诱导TLR4信号通路在内毒素血症中起着至关重要的作用。LPS诱导TLR4激活后,激活丝裂原活化蛋白激酶(MAPK)信号通路和转录核因子κB(NF-κB)释放大量炎症因子,继而触发炎症级联反应。本文从LPS-TLR4信号通路调控的上游靶蛋白、LPS诱导的TLR4信号转导、LPS-TLR4信号通路调控的下游靶蛋白等3个方面,就基于LPS-TLR4信号通路治疗内毒素血症机制研究进行综述。

Toll-like receptors 4（TLR4）,an important member of the TLR family,is considered as gene encoding LPS receptors,and major receptors for identifying lipopolysaccharide（LPS）. LPS-induced TLR4 signaling pathway plays a key role in endotoxemia. After TLR4 activated by LPS,the mitogen-activated protein kinase（MAPK）signaling pathway and nuclear transcription factorκB（NF-κB）are activated and large amounts of inflammatory factors are released,triggering inflammatory cascade reaction. This article reviews the mechanisms of endotoxemia in treatment based on TLR4 signal pathway in three perspectives：the effects of LPS-TLR4 signaling pathway on the upstream target proteins,LPS-induced TLR4 signal transduction,and the downstream target proteins regulated by LPS-TLR4 signaling pathway.