Lignanoids from Solanum lyratum

白英中木脂素类化学成分研究

In the present study,we aimed to investigate the chemical constituents from Solanum lyratum.The constituents were separated by column chromatography on silica gel,Sephadex LH-20 and preparative HPLC.Their structures were elucidated by spectroscopic means.A total of 13 compounds were isolated from S.lyraturn and identified as syringin(1),(+)-isolariciresinol(2),(+)-syringaresinol(3),leptolepisol D(4),(-)-secoisolariciresinol(5),(-)-epi-syringaresinol(6),aviculin(7),zhebeiresinol(8),ciwujiatone(9),(-)-(7′S,8S,8′R)-4,4′-dihydroxy-3,3′,5,5′-tetramethoxy-7′,9-epoxylignan-9′-ol-7-one(10),(+)-lariciresinol(11),(+)-pinoresinol(12)and(+)-medioresinol(13).All the compounds were isolated from S.lyratum for the first time.

对中药白英的木脂素类成分进行深入研究。通过正相硅胶柱色谱、Sephadex LH-20凝胶柱色谱及制备高效液相色谱技术进行分离纯化,利用理化性质及波谱分析技术(^(1)H NMR、^(13)C NMR)共鉴定了13个化合物,分别为紫丁香苷(1)、(+)-异落叶松脂素(2)、(+)-丁香脂醇(3)、leptolepisol D(4)、(–)-开环异裂松脂素(5)、(–)-表丁香脂素(6)、aviculin(7)、浙贝素(8)、刺五加酮(9)、(–)-(7′S,8S,8′R)-4,4′-二羟基-3,3′,5,5′-四甲氧基7′,9-单环氧木脂素-9′-醇-7-酮(10)、(+)-松脂醇(11)、(+)-松脂素(12)、(+)-杜仲树脂酚(13)。这些化合物均为首次从白英中分离得到。