益气活血固肾法治疗早期糖尿病肾病临床观察

Clinical Observation of the Method of Reinforcing Qi, Activating Blood and Strengthening the Kidney for Early Diabetic Nephropathy

目的:观察益气活血固肾法治疗早期糖尿病肾病的临床疗效。方法:将150例早期糖尿病肾病患者随机分为2组,治疗组76例,对照组74例。对照组给予常规的生活方式指导、降糖、降压及降脂治疗等常规治疗,治疗组在对照组治疗基础上加服益气活血固肾中药汤剂。2组疗程均为3月。观察2组空腹血糖、糖化血红蛋白、血脂、肾功能及临床疗效。结果:总有效率治疗组81.6%,对照组67.6%,2组临床疗效比较,差异有统计学意义(P<0.05)。治疗后,治疗组血糖指标空腹血糖(FBG)、糖化血红蛋白(HbA1c),胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),血肌酐(SCr)、血尿素氮(BUN)、尿微量白蛋白(mAlb)、肾小球滤过率(eGFR)、胱抑素C(Cys-C)分别与对照组比较,差异均有统计学意义(P<0.05),治疗组优于对照组。结论:益气活血固肾法治疗早期糖尿病肾病,除降糖降脂外,能明显改善肾功能。

Objective：To observe the clinical effect of the method of reinforcing qi,activating blood and strengthening the kidney for early diabetic nephropathy. Methods：Divided 150 cases of patients with early diabetic nephropathy into two groups randomly,the treatment group being 76 cases and the control group being 74 cases. The control group was given the routine treatment including the routine guidance of lifestyle,the treatment of lowering glucose,lipid and blood pressure and so on,while the treatment group additionally received Chinese herbal decoction of reinforcing qi,activating blood and strengthening the kidney orally. The course of treatment for both groups lasted for 3 months. Observe fasting blood glucose,glycosylated hemoglobin,blood lipid,renal function and the clinical effect. in the two groups. Results：The total effective rate was 81.6%in the treatment and 67.6% in the control group,difference being significant（P〈0.05）. After treatment,there were significant differences being found（P〈0.05）,when comparing the serum blood glucose indexes including fasting blood glucose（FBG） and glycosylated hemoglobin（HbA1c） as well as the serum lipids indexes including cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C）, low-density lipoprotein cholesterol（LDL-C）, serum creatinine（SCr）, blood urea nitrogen（BUN）,microalbuminuria（mAlb）,glomerular filtration rate（eGFR） and cystatin C（Cys-C） in the treatment group with those in the control group,and the treatment was better than the control group. Conclusion：The method of reinforcing qi,activating blood and strengthening the kidney for early diabetic nephropathy can not only lower the blood glucose and lipid, but also improve the renal function significantly.