当归补血汤加减联合常规疗法治疗尿毒症贫血临床观察

Clinical Observation of Modified Danggui Buxue Tang Combined with Routine Treatment for Uremia with Anemia

目的:观察当归补血汤加减联合常规疗法治疗尿毒症贫血的临床疗效。方法:选取本院60例尿毒症贫血患者,随机分为对照组和治疗组各30例。对照组予常规药物治疗,治疗组在对照组用药基础上联合当归补血汤加减。观察患者治疗前后血红蛋白(Hb)、红细胞压积(HCT)、C-反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及血清钾(K+)、谷丙转氨酶(ALT)水平的变化,记录患者中医症状的改善情况。结果:治疗组总有效率86.7%,对照组总有效率56.7%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组Hb及HCT水平均较治疗前升高(P<0.05),治疗组2项指标均较对照组升高更明显(P<0.05)。与治疗前比较,对照组治疗后CRP、IL-6及TNF-α水平均无明显改变(P>0.05)。治疗组治疗后3项指标均较治疗前降低(P<0.05)。治疗前后2组血清K+、ALT水平组内及组间比较,差异均无统计学意义(P>0.05)。结论:当归补血汤加减联合常规疗法能明显提高尿毒症贫血患者的Hb及HCT水平,降低炎症相关指标水平,改善临床症状,效果优于单纯使用常规疗法。

Objective：To observe the clinical effect of modified Danggui Buxue tang combined with routine treatment for uremic with anemia. Methods：Selected 60 cases of patients of uremic with anemia,and divided them into the observation group and the treatment group randomly, 30 cases in each group. The observation group was given routine drug for treatment, while the treatment group was additionally given modified Danggui Buxue tang for treatment. Observed the changes of levels of hemoglobin（Hb）, hematocrit（HCT）, C-reactive protein（CRP）, interleukin-6（IL-6）, tumor necrosis factor-α（TNF-α）, serum K（K^＋）, and alanine aminotransferase（ALT） before and after treatment, and recorded the improvement of Chinese medicine symptoms of patients. Results：The total effective rate was 86.7% in the treatment group and was 56.7% in the control group,difference being significant（P〈0.05）. After treatment,levels of Hb and HCT in two groups were both increased when compared with those before treatment（P〈0.05）. The increase of those two indexes in the treatment group was more obvious than that in the control group（P〈0.05）. Comparing with those before treatment,there were no significant changes being found in levels of CRP,IL-6 and TNF-α in the control group after treatment（P〈0.05）,while after treatment those three indexes in the treatment group were all decreased（P〈0.05）. There were no significant effect being found in the comparisons of levels of K＋ and ALT in intra-group and inter-group comparison（P〈0.05）. Conclusion：The therapy of modified Danggui Buxue tang combined with routine treatmentcan significantly increase levels of Hb and HCT in patients of uremic with anemia,reduce inflammation-relatedindex levels,and improve clinical symptoms,and its effect is better than the simple use of routine treatment.