中药辨证施治联合加巴喷丁治疗带状疱疹后遗神经痛临床观察

Clinical Observation of Syndrome Differentiation and Treatment of Chinese Medicine Combined with Gabapentin for Herpes Zoster Neuralgia

目的:观察中药辨证施治联合加巴喷丁胶囊治疗带状疱疹后遗神经痛的临床疗效。方法:将70例带状疱疹患者随机分为2组各35例;对照组采用西医常规治疗,治疗组在常规治疗的基础上施加中药辨证施治;观察和比较2组临床疗效,疼痛改善情况,应用止痛药物次数、加巴喷丁用量及不良反应发生情况。结果:总有效率治疗组91.43%,明显高于对照组71.43%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组疼痛视觉模拟评分法(VAS)评分均较治疗前下降,差异均有统计学意义(P<0.01,P<0.05);与对照组比较,治疗组VAS评分更低,2组比较,差异有统计学意义(P<0.01)。与对照组比较,治疗组应用止痛药物次数及加巴喷丁用量明显少于对照组,差异均有统计学意义(P<0.01)。治疗组不良反应总数是24例,占68.57%;对照组不良反应总数是28例,占80.00%,两者比较,差异无统计学意义(P>0.05);治疗组头晕、嗜睡、步态不稳例数少于对照组,腹痛、腹泻例数多于对照组,但差异均无统计学意义(P>0.05)。结论:中药辨证施治联合加巴喷丁治疗带状疱疹后遗神经痛,可以明显改善疼痛症状和提高治疗效果,减少止痛药物及加巴喷丁的应用。

Objective： To observe the clinical effect of syndrome differentiation and treatment of Chinese medicine combined with gabapentin for herpes zoster neuralgia. Methods：Divided 70 cases of patients with herpes zoster into the control group and the treatment group randomly,35 cases in each group. The control group was given routine treatment of western medicine, while the treatment group was additionally given syndrome differentiation and treatment of Chinese medicine based on the routine treatment. Observed and compared the clinical effect, improvement of pain, number of application of analgesic drugs,amount of gabapentin and occurrence of adverse reaction in two groups. Results：The total effective rate was 91.43% in the treatment group,being evidently higher than 71.43% in the control group,difference being significant（P〈0.05）. After treatment,Visual analogue scale（VAS） of in two groups were decreased when compared with those before treatment, differences being significant（P〈0.01, P〈0.05）. Compared with the control group,VAS in the treatment group was much lower,difference being significant（P〈0.01）. Compared with the control group,the number of application of analgesic drugs and amount of gabapentin in the treatment group were obviously less than those in the control group,differences being significant（P〈0.01）. The total number of adverse reaction was 24 in the control group,account for68.57%,while the total number of adverse reaction was 28 in the treatment group,account for 80.00%,difference being insignificant（P〈0.05）. The cases of dizziness,sleepiness and gait instability in the treatment group were less than those in the control group,while the cases of abdominal pain and diarrhea were more than those in the control group,differences being insignificant（P〈0.05）. Conclusion： The therapy of syndrome differentiation and treatment of Chinese medicine combined with gabapentin for herpes zoster neuralgia can significantly improve the pain symptoms, promote the curative effect,and reduce the application of analgesics drugs and gabapentin.