酒精性肝病患者血清白介素-8水平测定的临床价值

Clinical value of serum interleukin-8 detection in patients with alcoholic liver disease

目的探讨酒精性肝病(ALD)患者血清白介素-8(IL-8)水平测定的临床价值。方法选取我院收治的ALD患者136例作为ALD组,包括酒精性脂肪肝(AF)64例,酒精性肝炎(AH)43例,酒精性肝硬化(AC)29例。选取同一时期在我院接受治疗的55例非酒精性脂肪肝病(NAFLD)患者作为NAFLD组。通过Logistic回归模型及ROC曲线评价IL-8及其他指标对ALD的诊断价值。结果 ALD组患者血清IL-8水平高于NAFLD组(P<0.05);ALD组AH、AC患者血清IL-8水平明显高于NAFLD组患者(P<0.05)。IL-8单独诊断ADL的ROC曲线面积仅次于AST/ALT(P<0.05),IL-8与AST/ALT联合诊断ADL的ROC曲线下面积最大(AUC=0.912,P<0.05)。结论血清IL-8在ALD中有较高的诊断价值,与AST/ALT联合诊断价值更高。

Objective To investigate the clinical value of serum interleukin-8（IL-8） detection in patients with alcoholic liver disease（ALD）. Methods A total of 136 ADL patients admitted in our hospital were selected as the ADL group,including 64 cases of alcoholic fatty liver（AF）, 43 cases of alcoholic hepatitis（AH） and 29 cases of alcoholic liver cirrhosis（AC）. Fifty-five non-alcoholic fatty liver disease（NAFLD） patients admitted in our hospital at the same period were enrolled as the NAFLD group. The diagnostic value of IL-8 and other indexes for ALD was evaluated by Logistic regression model and ROC curve. Results The scrum IL-8 level of the ALD group was higher than that of the NAFLD group（P〈0.05）,and the scrum IL-8 levels of AH and AC patients in the ALD group were higher than those of patients in the NAFLD group（P〈0.05）. The area of ROC curve of ADL diagnosed by IL-8 alone was second only next to that of AST/ALT（P〈0.05）.The ROC curve of combined diagnosis of ADL showed that the area diagnosed by IL-8 combined with AST/ALT was the largest（P〈0.05）. Conclusion Serum IL-8 has high diagnostic value in ADL, and the diagnostic efficacy of joint detection between IL-8 and AST/ALT is higher than any of single diagnosis.