拉贝洛尔联合硫酸镁对妊娠高血压疾病母婴结局的影响

Effect of labetalol combined with magnesium sulfate on maternal and infant outcomes of hypertensive disorders in pregnancy

目的探讨拉贝洛尔联合硫酸镁对妊娠高血压疾病(HDP)母婴结局的影响。方法选取84例HDP患者,将其随机分为对照组(42例)及研究组(42例)。对照组予硫酸镁治疗,研究组予拉贝洛尔+硫酸镁治疗,比较两组治疗前、后血压的变化、母婴结局。结果两组治疗后收缩压、舒张压均降低,且研究组均低于对照组(P<0.05)。研究组终止妊娠、产后出血、胎盘早剥、产程异常、胎儿窘迫、早产儿发生率均低于对照组(P<0.05)。结论拉贝洛尔联合硫酸镁干预HDP患者能有效控制血压,可有效改善母婴结局。

Objective To investigate the effect of labetalol combined with magnesium sulfate on maternal and infant outcomes of hypertensive disorders in pregnancy（HDP）. Methods A total of 84 HDP patients were selected and randomly divided into control group（n=42） and study group（n=42）. The control group was treated with magnesium sulfate, the study group was treated with labetalol ＋magnesium sulfate. The blood pressure before and after treatment and the outcomes of maternal and infant were compared between the two groups. Results After treatment, the systolic pressure and diastolic pressure of the two groups decreased, and those in the study group were lower than the control group（P〈0.05）. The incidences of termination in pregnancy, postpartum hemorrhage, placental abruption, abnormal labor course, fetal distress and premature infants in the study group were lower than those in the control group（P〈0.05）. Conclusion Labetalol combined with magnesium sulfate in HDP can effectively control blood pressure, it can effectively improve the maternal and infant outcomes.