诱导化疗在局部晚期鼻咽癌中的研究进展

Research progress of induction chemotherapy for locally advanced nasopharyngeal carcinoma

放疗为主的综合治疗是鼻咽癌的主要治疗手段。随着调强适形放疗技术的大量开展和放化疗综合治疗的广泛应用,多项临床研究支持将同步放化疗作为局部晚期鼻咽癌的标准疗法,可显著提高治疗效果。远处转移和局部复发已成为鼻咽癌治疗失败的两个最主要原因,因此诱导化疗成为近年来鼻咽癌综合治疗的研究热点。诱导化疗联合同步放化疗的疗效及诱导化疗方案的选择也一直存在争议。因此,本文就诱导化疗联合同步放化疗治疗局部晚期鼻咽癌的疗效及其优选化疗方案作一综述。

The main treatment method for nasopharyngeal carcinoma is radiotherapy. With the development of intensity modulated radiation therapy and the extensive application of comprehensive treatment with radiotherapy and chemotherapy,a number of clinical studies support concurrent chemoradiotherapy as the standard treatment for locally advanced nasopharyngeal carcinoma,significantly improving the effect of treatment. Distant metastasis and local recurrence have become the two main reasons for the failure of the treatment for nasopharyngeal carcinoma. Induction chemotherapy has become a hot topic in the recent comprehensive treatment of nasopharyngeal carcinoma. It has been controversial about the effect of induction chemotherapy combined with concurrent chemoradiotherapy and the choice of induction chemotherapy regimen. Therefore,this article reviewed the efficacy and optimal regimen of induction chemotherapy in the treatment of locally advanced nasopharyngeal carcinoma.