早产儿目标血氧饱和度范围的争议

Controversial on target range of oxygen saturation in preterm infants

氧疗是危重早产儿救治的重要措施,但不恰当的氧疗会导致早产儿不良预后的发生,氧疗是否适当主要根据血氧饱和度监测及是否发生低氧或高氧损伤。长期以来国内外对早产儿目标血氧饱和度范围进行了许多研究,但结果有较大差别,对早产儿最合适的目标血氧饱和度范围仍未有定论。最近10年来,针对早产儿血氧饱和度开展多中心前瞻性大样本研究,结果显示早产儿生后早期使用较低血氧饱和度可以降低严重早产儿视网膜病的发生率,但病死率会有所升高。

Oxygen therapy plays an important role in the management of preterm infants,but inappropriate oxygen therapy will cause adverse neurodevelopmental outcome in preterm infants.Monitoring of oxygen saturation is essential in oxygen therapy.However,optimal range of oxygen saturation for preterm infants still remain controversial. In order to solve the clinical dilemma,many prospective multi-center randomized trials about optimal range of oxygen saturation for preterm infants has been completed.Lower target of oxygen saturation（85-89%）may result in a lower incidence of retinopathy of prematurity but higher rate of death than higher oxygen saturation target in preterm infants.