淋巴细胞减少诱导的T细胞稳态增殖在抗肿瘤免疫治疗中的研究

Research progresses of lymphopenia induced T cell homeostatic proliferation in antitumor immunity

机体在一定程度上能维持自身T细胞数量的稳定。淋巴细胞减少诱导的T细胞的稳态增殖由于缺少外来抗原及炎性因子的刺激，能重新识别包括肿瘤抗原在内的自身抗原。这一过程能打破原有免疫耐受状态，并产生抗肿瘤免疫效应。稳态增殖过程中会产生一些负性免疫分子的募集，削弱稳态增殖在抗肿瘤免疫中的作用。

Generally speaking, the organism can maintain the stability of T cells. The lymphopenia- induced homeostatic proliferation of T ceils could be driven by the recognition of autoantigen including tumor antigen in the absence of foreign antigens or inflammatory signals. This process can break tumor-induced immune tolerance and induce a powerful antitumor immunity. It is confirmed that some negative immune molecules are recruited during the homeostatic proliferation, then the autitumor immunity will be impaired.