摘要
机体在一定程度上能维持自身T细胞数量的稳定。淋巴细胞减少诱导的T细胞的稳态增殖由于缺少外来抗原及炎性因子的刺激,能重新识别包括肿瘤抗原在内的自身抗原。这一过程能打破原有免疫耐受状态,并产生抗肿瘤免疫效应。稳态增殖过程中会产生一些负性免疫分子的募集,削弱稳态增殖在抗肿瘤免疫中的作用。
Generally speaking, the organism can maintain the stability of T cells. The lymphopenia- induced homeostatic proliferation of T ceils could be driven by the recognition of autoantigen including tumor antigen in the absence of foreign antigens or inflammatory signals. This process can break tumor-induced immune tolerance and induce a powerful antitumor immunity. It is confirmed that some negative immune molecules are recruited during the homeostatic proliferation, then the autitumor immunity will be impaired.
作者
赖楠
陈泽宏
杨子科
刘严友葓
康世均
Lai Nan,Chen Zehong, Yang Zike, Liu Yanyouhong, Kang Shijun(Cancer Center, Integrated Hospital of Tra- ditional Chinese Medicine, Southern Medical University, Guangzhou 510315, Chin)
出处
《国际肿瘤学杂志》
CAS
2018年第2期100-102,共3页
Journal of International Oncology
基金
国家自然科学基金(81372449)