摘要
合成了未见文献报道的二茂铁取代的香豆素衍生物（FLC）,采用FT-IR、^1HNMR、^13CNMR和ESI-MS对其结构进行表征,利用紫外-可见分光光度法研究了FLC及与其类似结构的呋喃香豆素（FNC）对DPPH自由基、ABTS自由基和Galvinoxyl自由基的清除活性。结果表明,两种药物均不具有捕获Galvinoxyl自由基的能力;对DPPH自由基具有较好的清除能力;在捕获ABTS自由基能力测试中,化合物FNC的抗氧化效果优于化合物FLC。
One new ferrocenyl substituted coumarin derivative（FLC） was designed and synthesized for the first time,and its structure was characterized by FT-IR,^1 HNMR,^13 CNMR and ESI-MS. The antioxidant activities were determinate with DPPH,ABTS and Galvinoxyl radicals by ultraviolet-visible spectrophotometry,comparing with furan coumarin（FNC） containing similar structure.The results showed that two kinds of compounds were non-effective in scavenging Galvinoxyl radical,and have a good ability to scavenging DPPH radical,and while the compound FNC exhibited more obviously antioxidant activity than compound FLC against ABTS radical.
作者
孟宪娇
曹端林
李生玲
马文兵
MENG Xian-jiao, CAO Duan-lin, LI Sheng-ling, MA Wen-bing(School of Chemical Engineering and Technology, North University of China, Taiyuan 030051, Chin)
出处
《化学试剂》
CAS
北大核心
2018年第5期471-474,共4页
Chemical Reagents
关键词
二茂铁
香豆素
抗氧化
ferrocenyl
coumarin
antioxidant
