大株红景天通过联合西药治疗冠状动脉搭桥术后心肌梗塞的效果比较分析

Comparative Analysis of Effect of Salvia Miltiorrhiza Citrate and Sofren on Myocardial Infarction after Coronary Artery Bypass Grafting

目的：探究中西药联合治疗搭桥术后发生心肌梗塞的临床疗效。方法：选择2007年7月—2016年10月接受冠状动脉搭桥术治疗后发生心肌梗塞的患者62例,根据数字表法分为中西药联合组（实验组）、单纯西药组（对照组）,每组各31例。对照组采取常规西药治疗,实验组在对照组的基础上加用大株红景天注射液。对两组患者治疗前后的血清酶、血脂、心肌炎性环境和发生因素等进行比较分析。结果：两组患者在接受治疗前血清酶指标之间无显著性差异,治疗后各酶含量发生显著性降低,组间比较治疗后实验组各酶含量较对照组显著下降（P〈0.05）。两组患者血脂指标治疗后与治疗前比较发生显著变化（P〈0.05）,治疗后组间比较,实验组较对照组血脂指标显著改善（P〈0.05）。治疗后组间比较,实验组血清NO水平上升,ET-1、IL-6和TNF-α均有显著性下降,血小板显著上升,同时血小板凝集率和尿液中11-DH-TXB2含量显著下降,组间比较显示,实验组较对照组显著改善,具有统计学意义（P〈0.05）。结论：搭桥术后发生心肌梗塞时,使用大株红景天注射液联合西药能够更加有效的缓解心肌梗塞和维持机体血脂血清酶的稳态,同时有效地改善心肌炎性环境和降低心肌梗塞发生的风险,具有重要的临床意义。

Objective： To investigate the clinical efficacy of combined treatment of Chinese and Western medicine in the treatment of recurrent myocardial infarction after bypass surgery. Methods： Sixty-two cases for heart surgery received artery bypass grafting for the treatment of recurrent myocardial infarction from July 2007 to October 2016,were randomly divided into the combined Chinese and Western medicine group（experimental group）,Western medicine group（control group）,31 cases in each group. The control group was treated with conventional Western medicine,and the experimental group was injected with sodium silicate and Sofren Injection on the basis of the control group. The serum enzymes,blood lipid,myocarditis,environment and recurrence factors of the two groups before and after treatment were compared and analyzed. Results： There was no significant difference between the two groups＇ erum enzyme indexes before receiving treatment. Before and after treatment,the content of each enzyme decreased significantly. The treatment group＇s enzyme content significantly decreased compared to that of the control group（P〈0. 05）. The blood lipid indexes of the two groups were significantly changed compared with those before treatment（P〈0. 05）. After treatment,the blood lipid indexes of the experimental group were significantly improved（P〈0. 05）. After treatment,serum NO in the experimental group increased,ET-1,IL-6 and TNF-α decreased significantly,with statistical significance（P〈0. 05）. After treatment,platelets increased significantly,while platelet aggregation rate and urine 11-DH-TXB2 content decreased significantly. The comparison between the two groups showed that the experimental group was significantly improved compared with the control group（P〈0. 05）. Conclusion： For bypass postoperative recurrence of myocardial infarction,the use of Sofren Injection and Salvianolate Injection combined with Western medicine can effectively alleviate myocardial infarction and maintain blood lipid of serum enzyme in steady state,while effectively improve the inflammatory environment and reduce the risk of recurrence of myocardial infarction,with important clinical significance.