猪流行性腹泻病毒结构蛋白的研究进展

Advances in structural proteins of porcine epidemic diarrhea virus

猪流行性腹泻是由猪流行性腹泻病毒（PEDV）引起的一种急性、高度传染性的肠道疾病,PEDV由4个结构蛋白、15个非结构蛋白和ORF3组成。15个非结构蛋白仅在病毒复制过程中发挥了一定的作用,而4个结构蛋白构成了整个病毒颗粒,在病毒的复制和转录过程中均发挥了重要的作用。现对结构蛋白S（纤突蛋白）、M（小包膜糖蛋白）、E（膜糖蛋白）和N（核衣壳蛋白）在病毒复制和转录中的作用、免疫保护中的作用以及在细胞侵入及流行病学中的作用进行综述。

Porcine epidemic diarrhea is an acute, highly contagious intestinal disease caused by porcine epidemic diarrhea virus which consists of four structural proteins, 15 nonstructural proteins and ORF3. Fifteen nonstructural proteins play a role only in the process of viral replication, and the four structural proteins constitute the whole virus particles which play an important role in the replication and transcrip- tion of the virus. This paper summarizes the roles of structural proteins S, M, E, N in viral replication and transcription, in immune protec- tion and in cell invasion and epidemiology.