利拉鲁肽对初发2型糖尿病患者短期糖脂代谢的影响

Effects of liraglutide on short-term glucolipid metabolism in patients with primary type 2 diabetes mellitus

目的观察利拉鲁肽治疗初发2型糖尿病的临床疗效,探讨其对患者血糖、血脂及体重指数(BMI)的影响。方法选取2016-01~2017-05期间住院的2型糖尿病患者20例,给予利拉鲁肽1次/d皮下注射,第1周0.6 mg/d,第2周1.2 mg/d,维持1.2 mg/d。观察治疗前、治疗2周及治疗4周的血糖、血脂、BMI变化。结果与治疗前比较,治疗2周空腹血糖(FBG)、餐后2 h血糖(PBG)降低(P<0.05)。治疗4周FBG、PBG显著降低(P<0.01),甘油三酯(TG)、低密度脂蛋白(LDL)、BMI降低(P<0.05)。治疗2周、4周胆固醇(TC)、高密度脂蛋白(HDL)、空腹胰岛素(FINS)、餐后2 h胰岛素(PINS)未见明显改变。结论利拉鲁肽治疗初发2型糖尿病短期降糖、降脂效果显著,尤其适用于肥胖糖尿病患者,值得临床应用推广。

Objective To observe the clinical effect of liraglutide on newly diagnosed type 2 diabetes mellitus,and to investigate the effects of liraglutide on the patients＇ blood glucose,blood lipid and body mass index（ BMI）. Methods During January 2016 and May 2017,20 inpatients with type 2 diabetes mellitus received liraglutide treatment for 4 weeks. During the period of liraglutide treatment,liraglutide was subcutaneously injected to the patients at 0. 6 mg/d during the first week and the dosage was increased to 1. 2 mg/d during the second week and the dosage of 1. 2 mg/d was maintained to the end of the treatment. The changes of blood glucose,blood lipid and BMI were observed before and two and four weeks after treatment. Results Compared with those before treatment,FBG and PBG decreased two weeks after treatment（ P〈0. 05）,and TG,LDL,BMI,FBG and PBG decreased four weeks after treatment（ P〈0. 05）. There were no significant changes in TC,HDL,FINS and PINS before and two and four weeks after treatment. Conclusion Liraglutide has significant short-term hypoglycemic and hypolipidemic effects on the patients with newly diagnosed type 2 diabetes,especially on the obese patients with diabetes.