高尿酸血症患病率及其与雌二醇水平相关性分析

The prevalence rate of hyperuricemia and its relationship to estradiol

目的分析惠州地区高尿酸血症患病率,探讨血清雌二醇水平与高尿酸症之间的相关性。方法选择惠州市第一人民医院500名体检人员为研究对象,检测血清中尿酸浓度,女性同时检测雌二醇。结果惠州地区高尿酸血症总患病率为23.2%(116/500),男性及女性分别为27.91%(72/258)和18.18%(44/242)(χ~2=6.628,P=0.010),不同性别血清尿酸浓度差异显著(Z=-15.961,P<0.001)。各年龄段男性血清尿酸水平(χ~2=6.432,P=0.169)及患病率(χ~2=3.989,P=0.408)均相近。50岁以上女性患病率与男性无差异(χ~2=0.088,P=0.766),20~49岁女性血清尿酸水平(Z=-3.856,P<0.001)及患病率(χ~2=9.532,P=0.002)均低于50岁以上女性。20~49岁女性雌二醇高于50岁以上女性(Z=-6.171,P<0.001),尿酸与雌二醇具有负相关性,r=-0.464。结论除50岁以上女性外,惠州地区健康人群高尿酸血症患病率与国内多数地区人群相近,女性50岁进入绝经期后高尿酸血症患病率的快速上升与体内雌激素下降呈负相关。

Objective To analyze the prevalence rate of hyperuricemia（HUA） in Huizhou and investigate the relationship between HUA and estradiol（ E2）. Methods 500 health people from Huizhou first hospital were enrolled. Uric acid and E2 in female was detected. Results The overall prevalence rate of HUA was 23. 2%（116/500）. The prevalence rate of male and female were 27. 91%（72/258） and 18. 18%（44/242）,respectively（ χ~2= 6. 628,P = 0. 010）. There was no significantly difference between male and female in the level of uric acid（ Z =-15. 961,P 〈 0. 001） The levels of uricacid in serum（ χ~2= 6. 432,P = 0. 169） and the prevalence rate（ χ~2= 1. 1,P 〉 0. 05） were closed to each age bracket in male group. The prevalence rate of male over 50 years old was closed to female（ χ~2= 0. 0144,P 〉 0. 05）. In 20 to 49 years old female group,prevalence rate was lower（ χ~2= 6. 084,P 〈 0. 025） and uric acid in serum（ χ~2= 17. 599,P 〈0. 001） was lower than that of the group over 50 years old. The levels of E2 of female under 50 years old was higher than that above 50 years old（ χ~2= 41. 292,P 〈 0. 001）. There was negative correlation between uric acid and E2,and the correlation coefficient was-0. 464. Concusion The prevalence rate of HUA in Huizhou is close to most area in China except female over 50 years old. After menopause,the rapid rise of prevalence rate of HUA in female is associated with the descending of E2.