2型糖尿病男性患者血尿酸水平与急性脑梗死的相关性及其临床意义

Relationship between serum uric acid level and acute cerebral infarction in male patients with type 2 diabetes mellitus and its clinical significance

目的:探讨2型糖尿病(T2DM)男性患者血尿酸水平与急性脑梗死的相关性及其临床意义。方法:选择2014年7月至2016年12月住院的男性2型糖尿病急性脑梗死患者64例作为研究对象,入组后检测血尿酸(SUA),空腹血糖(FPG),糖化血红蛋白(Hb Alc),甘油三酯(TG),发病后2~3 d颅脑CT测量梗死病灶大小,采用美国国立卫生研究院脑卒中量表(NIHSS)于患者入组时测定神经功能状况。结果:SUA≥642.5μmol/L患者的FPG、HbA_1C、TG、梗死病灶及NIHSS水平均高于SUA<642.5μmol/L患者(P<0.05);SUA与FPG、HbA_1C、TG、梗死病灶及NIHSS评分均呈正相关性(P<0.05)。结论:SUA水平与FPG、HbA_1C、TG、梗死病灶及NIHSS评分存在相关性,及早检测SUA水平有助于病情程度判断及神经功能障碍预测。

Objective： To investigate the relationship between serum uric acid level and acute cerebral infarction in type 2 diabetic male patients and its clinical significance. Methods： Sixty-four male patients with type 2 diabetes mellitus（ T2DM） who were hospitalized from July 2014 to December 2016 were enrolled in this study. Serum uric acid（ SUA）,fasting plasma glucose（ FPG）,glycosylated Hemoglobin（ Hb Alc） and triglyceride（ TG） were measured at 2-3 days after onset. The infarct size was measured by brain CT. The NIH Stroke Scale（ NIHSS） was used to measure the neurological status of patients. Results： In patients with SUA≥642. 5μmol/L,FPG（ 10. 45 ± 1. 84 mmol/L vs 9. 23 ± 1. 46 mmol/L）,HbA1C（ 9. 68 ± 1. 65 % vs 8. 44 ± 1. 07 %）,TG（ 5. 51 ± 1. 49 mmol/L vs4. 27 ± 1. 20 mmol/L）,the levels of infarction（ 4. 18 ± 1. 43 cm vs 3. 04 ± 1. 16 cm） and NIHSS（ 8. 19 ± 2. 41 vs 6. 53 ± 1. 72） were significantly higher than those of SUA 642. 5 μmol/L（ R = 0. 494,p = 0. 004）. The correlation between SUA and FPG（ r = 0. 499,p = 0. 004）,HbA1C,TG,infarct size and NIHSS score（ r = 0. 795,p 0. 001） showed a significant positive correlation（ P〈0. 05）. Conclusion： There is a significant positive correlation between SUA level and FPG,HbA1C,TG,infarct size and NIHSS score. Early detection of SUA level is helpful to predict the severity of illness and predict neurological dysfunction.