低剂量异丙嗪治疗小儿肠道病毒感染致剧烈呕吐的疗效

Effect of low-dose promethazine on enterovirus infection-induced vomiting in children

目的:观察低剂量异丙嗪治疗小儿肠道病毒感染致剧烈呕吐疗效。方法:选择肠道病毒感染致剧烈呕吐患儿150例,根据不同的治疗方法将其分为对照组(甲氧氯普胺治疗)与观察组(低剂量异丙嗪治疗)各75例,对比分析两组临床治疗有效率、并发症发生率。结果:观察组临床治疗有效率高于对照组(P<0.05),并发症发生率低于对照组(P<0.05)。结论:在小儿肠道病毒感染致剧烈呕吐的临床治疗中,应用低剂量异丙嗪治疗,临床治疗效果明显且没有并发症发生,安全性较高,值得临床推广应用。

Objective： To observe the effect of low-dose promethazine in the treatment of severe vomiting caused by enterovirus infection in children. Methods： One hundred and fifty children with intestinal infection were enrolled and divided into two groups according to different treatment methods. The control group was given metoclopramide treatment and the treatment group was given low-dose promethazine treatment. Comparative analysis of clinical treatment efficiency and the incidence of complications was conducted in the two groups. Results： The effective rate of clinical treatment in the treatment group was significantly higher than that of the control group,and the incidence rate of complication in the treatment group was significantly lower than that of the control group（ P〈0. 05）. Conclusion： Low-dose promethazine is recommended in the clinical treatment of children with severe vomiting caused by enterovirus infection. The effect of clinical treatment with low-dose promethazine is remarkable,and there is no complication with high safety. It is worthy of clinical application.