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宫颈癌组织人类白细胞抗原F表达变化及其与患者临床病理参数的关系 被引量:2

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摘要 目的观察宫颈癌组织人类白细胞抗原F(HLA-F)表达变化,并分析其表达与患者临床病理参数的关系。方法选择宫颈癌组织115例份及其配对的癌旁正常组织20例份,采用免疫组化法检测各组织HLA-F表达,并分析其表达与宫颈癌患者临床病理参数的关系。结果宫颈癌组织HLA-F表达明显高于癌旁正常组织(P<0.01)。宫颈癌组织HLA-F表达与患者组织学类型、肿瘤直径以及浸润深度有关(P均<0.05),与患者年龄、组织分化程度、临床分期及淋巴结转移情况无关(P均>0.05)。结论宫颈癌组织HLA-F表达升高,其表达变化可能参与了宫颈癌的发生、发展。
出处 《山东医药》 CAS 2018年第16期89-91,共3页 Shandong Medical Journal
基金 山东省自然科学基金资助项目(ZR2013HM060) 山东省科技发展计划(2014GSF118048)
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